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首页> 外文期刊>Molecular Carcinogenesis >Simian virus 40 (SV40)-like DNA sequences not detectable in finnish mesothelioma patients not exposed to SV40-contaminated polio vaccines.
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Simian virus 40 (SV40)-like DNA sequences not detectable in finnish mesothelioma patients not exposed to SV40-contaminated polio vaccines.

机译：在未暴露于受SV40污染的脊髓灰质炎疫苗的芬兰间皮瘤患者中无法检测到类似猿猴病毒40（SV40）的DNA序列。

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摘要

Occupational asbestos exposure can be demonstrated in 80% of mesothelioma cases. A possible role of simian virus 40 (SV40) in the etiology of mesothelioma was raised because several studies reported the presence and expression of SV40-like DNA sequences in human mesotheliomas. It is also known that expression of SV40 large T antigen inhibits cellular Rb and p53. This suggests that SV40 might render infected cells more susceptible to asbestos carcinogenicity. The SV40-like sequences are suggested to have arisen from contaminated polio vaccines. Millions of people in the United States and most European countries were inoculated with SV40-contaminated polio vaccine in 1955-1963. However, in Finland, where polio vaccination started in 1957, no SV40-contaminated vaccine was used. We used a polymerase chain reaction-based method to test for the presence of SV40-like sequences in DNA extracted from the frozen tumor tissues of 49 Finnish mesothelioma patients, most of whom had been occupationally exposed to asbestos. All of the Finnish tumor tissues tested negative for SV40-like sequences. The results suggest that the SV40-like sequences detected in mesothelioma tissue in some previous studies may indeed originate from SV40-contaminated polio vaccines. It is a matter of speculation whether the absence of SV40 infection has contributed to the relatively low incidence of mesothelioma in Finland (1/10(5) in 1990-1995). Copyright 1999 Wiley-Liss, Inc.
机译：在80％的间皮瘤病例中可证明职业性石棉接触。猿猴病毒40（SV40）在间皮瘤的病因中可能发挥了作用，因为一些研究报道了人间皮瘤中SV40样DNA序列的存在和表达。还已知SV40大T抗原的表达抑制细胞Rb和p53。这表明SV40可能会使受感染的细胞更容易受到石棉致癌性的影响。 SV40样序列被认为是受污染的脊髓灰质炎疫苗产生的。在1955-1963年，美国和大多数欧洲国家的数百万人接种了被SV40污染的脊髓灰质炎疫苗。但是，在1957年开始进行脊髓灰质炎疫苗接种的芬兰，没有使用受SV40污染的疫苗。我们使用基于聚合酶链反应的方法来测试从49名芬兰间皮瘤患者冷冻肿瘤组织中提取的DNA中是否存在SV40样序列，其中大多数患者职业性接触石棉。所有芬兰肿瘤组织的SV40样序列测试均为阴性。结果表明，在先前的一些研究中，间皮瘤组织中检测到的SV40样序列确实可能源自受SV40污染的脊髓灰质炎疫苗。芬兰是否存在SV40感染是否导致间皮瘤的发病率相对较低（1990-1995年为1/10（5）），是一个推测的问题。版权所有1999 Wiley-Liss，Inc.

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