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首页> 外文期刊>Molecular cell >Photoactivated phytochrome induces rapid PIF3 phosphorylation prior to proteasorne-mediated degradation
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Photoactivated phytochrome induces rapid PIF3 phosphorylation prior to proteasorne-mediated degradation

机译：光活化的植物色素在蛋白酶体介导的降解之前诱导快速的PIF3磷酸化

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摘要

Following light-induced nuclear translocation, specific members of the phytochrome (phy) photoreceptor family (phyA to phyE) interact with bHLH transcription factors, such as PIF3, and induce changes in targetgene expression. The biochemical mechanism comprising signal transfer from phy to PIF3 has remained undefined but results in rapid degradation of PIF3. We provide evidence that photoactivation of phy induces rapid in vivo phosphorylation of PIF3 preceding degradation. Both phyA and phyB redundantly induce this PIF3 phosphorylation, as well as nuclear speckle formation and degradation, by direct interaction with PIF3 via separate binding sites. These data suggest that phy-induced phosphorylation of proteins such as PIF3 may represent the primary intermolecular signaling transaction of the activated photoreceptor, tagging the target protein for proteosomal degradation, possibly in nuclear speckles.
机译：光诱导的核易位后，植物色素（phy）感光体家族的特定成员（phyA到phyE）与bHLH转录因子（例如PIF3）相互作用，并诱导靶基因表达的变化。尚不确定包括从phy到PIF3的信号转移的生化机制，但会导致PIF3迅速降解。我们提供的证据是，phy的光活化会在降解之前诱导PIF3的体内快速磷酸化。 phyA和phyB都通过单独的结合位点与PIF3直接相互作用，从而多余地诱导了PIF3磷酸化以及核斑点的形成和降解。这些数据表明，phy诱导的蛋白质（例如PIF3）的磷酸化可能代表了活化感光器的主要分子间信号传导，标记了目标蛋白质的蛋白体降解（可能在核斑点中）。

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