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首页> 外文期刊>Molecular cell >Excision of the Drosophila mariner transposon mos1. Comparison with bacterial transposition and v(d)j recombination.
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Excision of the Drosophila mariner transposon mos1. Comparison with bacterial transposition and v(d)j recombination.

机译：果蝇水手转座子mos1的切除。与细菌转座和v（d）j重组的比较。

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摘要

It has been proposed that the modern immune system has evolved from a transposon in an ancient vertebrate. While much is known about the mechanism by which bacterial transposable elements catalyze double-strand breaks at their ends, less is known about how eukaryotic transposable elements carry out these reactions. We have examined the mechanism by which mariner, a eukaryotic transposable element, performs DNA cleavage. We show that the nontransferred strand is cleaved initially, unlike prokaryotic transposons which cleave the transferred strand first. First strand cleavage is not tightly coupled to second strand cleavage and can occur independently of synapsis, as happens in V(D)J recombination but not in transposition of prokaryotic transposons. Unlike V(D)J recombination, however, second strand cleavage of mariner does not occur via a hairpin intermediate.
机译：已经提出现代免疫系统已经从古代脊椎动物中的转座子进化而来。尽管人们对细菌可转座因子在其末端催化双链断裂的机理了解很多，但对真核转座因子如何进行这些反应的了解却很少。我们已经研究了水手真核转座因子执行DNA切割的机制。我们显示未转移的链最初被切割，不像原核转座子首先切割转移的链。第一链切割与第二链切割没有紧密结合，并且可以独立于突触而发生，如在V（D）J重组中发生的，但在原核转座子的转座中却没有。但是，与V（D）J重组不同，不会通过发夹状中间体发生水手的第二条链断裂。

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