Identification of a new cryptochrome class. Structure, function, and evolution.

Brudler R; Hitomi K; Daiyasu H; Toh H; Kucho K; Ishiura M; Kanehisa M; Roberts VA; Todo T; Tainer JA; Getzoff ED

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Identification of a new cryptochrome class. Structure, function, and evolution.

机译：识别新的隐色类。结构，功能和演变。

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Cryptochrome flavoproteins, which share sequence homology with light-dependent DNA repair photolyases, function as photoreceptors in plants and circadian clock components in animals. Here, we coupled sequencing of an Arabidopsis cryptochrome gene with phylogenetic, structural, and functional analyses to identify a new cryptochrome class (cryptochrome DASH) in bacteria and plants, suggesting that cryptochromes evolved before the divergence of eukaryotes and prokaryotes. The cryptochrome crystallographic structure, reported here for Synechocystis cryptochrome DASH, reveals commonalities with photolyases in DNA binding and redox-dependent function, despite distinct active-site and interaction surface features. Whole genome transcriptional profiling together with experimental confirmation of DNA binding indicated that Synechocystis cryptochrome DASH functions as a transcriptional repressor.

机译：与光依赖性DNA修复光解酶具有序列同源性的隐色黄素蛋白在植物中充当感光器，在动物中充当昼夜节律成分。在这里，我们将拟南芥隐色基因的测序与系统发育，结构和功能分析相结合，以鉴定细菌和植物中的新隐色类别（隐色DASH），这表明隐色在真核生物和原核生物发散之前就已经进化了。尽管这里有不同的活性部位和相互作用表面特征，但此处报道的隐孢子虫隐色染料DASH的隐色晶体学结构揭示了光解酶在DNA结合和氧化还原依赖性功能方面的共性。全基因组转录概况以及与DNA结合的实验确认表明，拟隐孢子虫隐色DASH发挥转录抑制因子的功能。

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《Molecular cell》 |2003年第1期|共9页
作者
Brudler R; Hitomi K; Daiyasu H; Toh H; Kucho K; Ishiura M; Kanehisa M; Roberts VA; Todo T; Tainer JA; Getzoff ED;
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正文语种 eng
中图分类分子生物学;细胞生物学;
关键词
cryptochrome; physiological aspects; binding; Identification (Psychology); 认同(心理学); 进化;

机译：cryptochrome;physiological aspects;binding;Identification (Psychology);认同(心理学);进化;

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1. Identification of a new cryptochrome class. Structure, function, and evolution. [J] . Brudler R, Hitomi K, Daiyasu H, Molecular cell . 2003,第1期

机译：识别新的隐色类。结构，功能和演变。
2. Structure/Function Analysis of Xenopus Cryptochromes 1 and 2 Reveals Differential Nuclear Localization Mechanisms and Functional Domains Important for Interaction with and Repression of CLOCK-BMAL1 [J] . Ellena A. van der Schalie, Francesca E. Conte, Karla E. Marz, Molecular and Cellular Biology . 2007,第6期

机译：爪蟾隐色染料1和2的结构/功能分析揭示了差异的核定位机制和功能域对于CLOCK-BMAL1的相互作用和抑制很重要。
3. Identification of a Novel Cryptochrome Differentiating Domain Required for Feedback Repression in Circadian Clock Function [J] . Sanjoy Khan, Haiyan Xu, Maki Ukai-Tadenuma, The Journal of biological chemistry . 2012,第31期

机译：在昼夜节日功能中识别反馈抑制所需的新型加密色彩区分域
4. STRUCTURE AND FUNCTIONING STRAPDOWN INERTIAL-TERMOPHOTOGRAMMETRIC SYSTEM OF STEREOSHOOTING AND IDENTIFICATION OF UNDERGROUND ARCHAELOGICAL TRACKS AND DEBRIS OF STRUCTURES [C] . R.A.Syngatulin, P.K.Plotnikov, A.P.Ramzaev Saint Petersburg International Conference on Integrated Navigation Systems . 2001

机译：结构与运作刻度终端光学晶体术终端微观术语及地下古代轨道识别与结构
5. A Genetic Study of the Structure-Function Relationships Underlying Cryptochrome Evolution [D] . Liu, Huachun . 2019

机译：隐藏着色进化潜在关系的基因研究
6. Structure/Function Analysis of Xenopus Cryptochromes 1 and 2 Reveals Differential Nuclear Localization Mechanisms and Functional Domains Important for Interaction with and Repression of CLOCK-BMAL1 [O] . Ellena A. van der Schalie, Francesca E. Conte, Karla E. Marz, 2007

机译：爪蟾隐色染料1和2的结构/功能分析揭示了差异性的核定位机制和功能域对于CLOCK-BMAL1的相互作用和抑制很重要。
7. Structures of Drosophila Cryptochrome and Mouse Cryptochrome1 Provide Insight into Circadian Function [O] . Czarna Anna, Berndt Alex, Singh Hari Raj, 2013

机译：果蝇Cryptochrome和小鼠Cryptochrome1的结构提供了昼夜节律功能的见解。

Identification of a new cryptochrome class. Structure, function, and evolution.

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