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首页> 外文期刊>Cardiology in review >Aspirin resistance: mechanisms and clinical implications.
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Aspirin resistance: mechanisms and clinical implications.

机译：阿司匹林抵抗：机制和临床意义。

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摘要

Acetylsalicylic acid (aspirin) has been shown to irreversibly interfere with platelet function, an effect that is associated with a reduction in morbid and mortal arterial thrombotic events in multiple clinical studies. This clinical benefit appears to be attenuated by resistance to the antiplatelet effects of aspirin in up to 35% of patients. The mechanisms for aspirin resistance are multifactorial and include noncompliance with aspirin therapy, diabetes mellitus, cell-cell and drug-drug interactions, genetic polymorphisms, and coronary artery disease. It has not been determined what the best laboratory procedure is to screen for aspirin resistance. Those individuals at high risk for aspirin resistance might best be treated with an additional oral antiplatelet drug (eg, clopidogrel) to achieve maximal protection against arterial thrombotic events.
机译：乙酰水杨酸（阿司匹林）已显示不可逆地干扰血小板功能，这一作用与多项临床研究中的病态和凡人血栓形成事件减少有关。这种临床益处似乎在多达35％的患者中因对阿司匹林的抗血小板作用的抗性而减弱。阿司匹林抵抗的机制是多方面的，包括不遵守阿司匹林治疗，糖尿病，细胞-细胞和药物相互作用，遗传多态性和冠状动脉疾病。尚未确定筛选阿司匹林耐药性的最佳实验室程序是什么。那些具有阿司匹林抗药性高风险的个体最好用其他口服抗血小板药物（例如氯吡格雷）治疗，以获得针对动脉血栓形成事件的最大保护。

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