Identification of BARD1 as mediator between proapoptotic stress and p53-dependent apoptosis.

Irminger-Finger I; Leung WC; Li J; Dubois-Dauphin M; Harb J; Feki A; Jefford CE; Soriano JV; Jaconi M; Montesano R; Krause KH

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Identification of BARD1 as mediator between proapoptotic stress and p53-dependent apoptosis.

机译：鉴定BARD1是促凋亡应激与p53依赖性细胞凋亡之间的介体。

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The BRCA1-associated protein BARD1 is a putative tumor suppressor. We suggest that BARD1 is a mediator of apoptosis since (1) cell death in vivo (ischemic stroke) and in vitro is accompanied by increased levels of BARD1 protein and mRNA; (2) overexpression of BARD1 induces cell death with all features of apoptosis; and (3) BARD1-repressed cells are defective for the apoptotic response to genotoxic stress. The proapoptotic activity of BARD1 involves binding to and elevations of p53. BRCA1 is not required for but partially counteracts apoptosis induction by BARD1. A tumor-associated mutation Q564H of BARD1 is defective in apoptosis induction, thus suggesting a role of BARD1 in tumor suppression by mediating the signaling from proapoptotic stress toward induction of apoptosis.

机译：BRCA1相关蛋白BARD1是推定的肿瘤抑制因子。我们建议BARD1是细胞凋亡的介体，因为（1）体内细胞死亡（缺血性中风）和体外细胞凋亡伴随着BARD1蛋白和mRNA水平的升高; （2）过表达的BARD1诱导细胞死亡，具有凋亡的所有特征; （3）BARD1抑制的细胞对遗传毒性应激的凋亡反应存在缺陷。 BARD1的促凋亡活性涉及与p53结合并升高p53。 BRCA1不是必需的，但可以部分抵消BARD1诱导的凋亡。 BARD1的肿瘤相关突变Q564H在凋亡诱导中存在缺陷，因此表明BARD1在肿瘤抑制中的作用是通过介导从细胞凋亡应激向凋亡诱导的信号传导。

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《Molecular cell》 |2001年第6期|共12页
作者
Irminger-Finger I; Leung WC; Li J; Dubois-Dauphin M; Harb J; Feki A; Jefford CE; Soriano JV; Jaconi M; Montesano R; Krause KH;
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正文语种 eng
中图分类分子生物学;细胞生物学;
关键词
Apoptosis; Carrier Proteins; Protein p53; 脱噬作用; 载体蛋白质类; 蛋白质P53;

机译：Apoptosis;Carrier Proteins;Protein p53;脱噬作用;载体蛋白质类;蛋白质P53;

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专利

1. Identification of BARD1 as mediator between proapoptotic stress and p53-dependent apoptosis. [J] . Irminger-Finger I, Leung WC, Li J, Molecular cell . 2001,第6期

机译：鉴定BARD1是促凋亡应激与p53依赖性细胞凋亡之间的介体。
2. Primary colorectal tumors fail to express the proapoptotic mediator PTAG and its reexpression augments drug-induced apoptosis. [J] . Bahar A, Whitby P, Holley S, Genes, Chromosomes and Cancer . 2007,第2期

机译：原发性结肠直肠肿瘤无法表达促凋亡介质PTAG，其重新表达增强了药物诱导的细胞凋亡。
3. Ectopic mTERT expression in mouse embryonic stem cells does not affect differentiation but confers resistance to differentiation- and stress-induced p53-dependent apoptosis. [J] . Lee MK, Hande MP, Sabapathy K Journal of Cell Science . 2005,第Pta4期

机译：小鼠胚胎干细胞中异位mTERT表达不影响分化，但赋予对分化和应激诱导的p53依赖性细胞凋亡的抗性。
4. CaMKII Mediates Angiotensin II-induced Cardiomyocytes Apoptosis. Role OF Ca~(2+), ROS and p38MAPK [C] . J. Palomeque, L. Sapia, C. Valverde, International Society for Heart Research . 2008

机译：Camkii介导血管紧张素II诱导的心肌细胞凋亡。 CA〜（2+），ROS和P38MAPK的作用
5. Amyloid beta-peptide (1-42)-mediated oxidative stress and neurotoxicity: I. The role of methionine 35. II. Proteomic identification of specifically oxidized proteins in models of Alzheimer's disease. [D] . Boyd-Kimball, Debra Lynn. 2004

机译：淀粉样β-肽（1-42）介导的氧化应激和神经毒性：I.蛋氨酸的作用35. II。蛋白质组学鉴定阿尔茨海默病模型中特定氧化的蛋白质。
6. Reactive oxygen species are downstream mediators of p53-dependent apoptosis. [O] . T M Johnson, Z X Yu, V J Ferrans, 1996

机译：活性氧是p53依赖性细胞凋亡的下游介质。
7. Identification of BARD1 as mediator between proapoptotic stress and p53-dependent apoptosis [O] . Irminger, Irmgard, Leung, W C., Li, Jia, 2001

机译：鉴定BARD1作为促凋亡应激与p53依赖性细胞凋亡之间的介体
8. SLC5A8-Mediated Switching of STAT3 from a Pro-Oncogenic Signal into a Proapoptotic Signal in Breast Cancer. Revision. [R] . Thangaraju, M. 2009

机译：sLC5a8介导的sTaT3从前致癌信号转换为乳腺癌中的促凋亡信号。修订。

Identification of BARD1 as mediator between proapoptotic stress and p53-dependent apoptosis.

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