Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: interference with early steps of viral replication.

Turelli P; Doucas V; Craig E; Mangeat B; Klages N; Evans R; Kalpana G; Trono D

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Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: interference with early steps of viral replication.

机译：传入的HIV预整合复合物上的INI1和PML的细胞质募集：干扰病毒复制的早期步骤。

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During the early phase of the retroviral life cycle, only a fraction of internalized virions end up integrating their genome into the chromosome, even though the resulting proviruses are almost systematically expressed. Here, we reveal that incoming retroviral preintegration complexes trigger the exportin-mediated cytoplasmic export of the SWI/SNF component INI1 and of the nuclear body constituent PML. We further show that the HIV genome associates with these proteins before nuclear migration. In the presence of arsenic, PML is sequestered in the nucleus, and the efficiency of HIV-mediated transduction is markedly increased. These results unveil a so far unsuspected cellular response that interferes with the early steps of HIV replication.

机译：在逆转录病毒生命周期的早期阶段，尽管产生的原病毒几乎系统地表达，但只有一小部分内部化的病毒体最终将其基因组整合到染色体中。在这里，我们揭示传入的逆转录病毒预整合复合物触发SWI / SNF组件INI1和核体成分PML的exportin介导的胞质出口。我们进一步表明，在核迁移之前，HIV基因组与这些蛋白质相关。在砷的存在下，PML被隔离在细胞核中，HIV介导的转导效率显着提高。这些结果揭示了迄今为止尚未发生的细胞反应，该反应干扰了HIV复制的早期步骤。

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《Molecular cell》 |2001年第6期|共10页
作者
Turelli P; Doucas V; Craig E; Mangeat B; Klages N; Evans R; Kalpana G; Trono D;
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正文语种 eng
中图分类分子生物学;细胞生物学;
关键词
DNA-Binding Proteins; HIV; HIV Infections; Neoplasm Proteins; Transcription Factors; DNA结合蛋白质类; HIV感染; 肿瘤蛋白质类; 转录因子; 病毒复制;

机译：DNA-Binding Proteins;HIV;HIV Infections;Neoplasm Proteins;Transcription Factors;DNA结合蛋白质类;HIV感染;肿瘤蛋白质类;转录因子;病毒复制;

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1. Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: interference with early steps of viral replication. [J] . Turelli P, Doucas V, Craig E, Molecular cell . 2001,第6期

机译：传入的HIV预整合复合物上的INI1和PML的细胞质募集：干扰病毒复制的早期步骤。
2. Quantitative monitoring of the cytoplasmic release of NCp7 proteins from individual HIV-1 viral cores during the early steps of infection [J] . Sarwat Zgheib, Iryna Lysova, Eleonore Réal, Scientific reports. . 2019,第1期

机译：感染早期阶段从单个HIV-1病毒核心中定量检测NCp7蛋白的胞质释放
3. High frequency of alternative splicing of human genes participating in the HIV-1 life cycle: a model using TSG101, betaTrCP, PPIA, INI1, NAF1, and PML. [J] . Favre M, Butticaz C, Stevenson B, JAIDS: Journal of acquired immune deficiency syndromes . 2003,第2期

机译：参与HIV-1生命周期的人类基因的可变剪接的高频率：使用TSG101，betaTrCP，PPIA，INI1，NAF1和PML的模型。
4. A molecular dynamics study of hiv-1 protease complexes with C_(60) and fullerene-based anti-viral agents [C] . Hai Mi, Mark E. Tuckerman, David I. Schuster, International symposium on recent advances in the chemistry and physics of fullerenes and related materials . 1999

机译：用C_（60）和富勒烯的抗病毒剂的HIV-1蛋白酶复合物的分子动力学研究
5. Genome-wide RNA-interference Screen for Human Host Factors Vital to Influenza A Virus-induced Cell Death and Viral Replication. [D] . Tran, Anh Thuy. 2013

机译：全基因组RNA干扰筛查至关重要的人类宿主因素对甲型流感病毒诱导的细胞死亡和病毒复制。
6. Dominant Negative MA-CA Fusion Protein Is Incorporated into HIV-1 Cores and Inhibits Nuclear Entry of Viral Preintegration Complexes [O] . Jordan Anderson-Daniels, Parmit K. Singh, Gregory A. Sowd, 2019

机译：显性负MA-CA融合蛋白被纳入HIV-1核心并抑制病毒预整合复合物的核进入。
7. Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: interference with early steps of viral replication [O] . Turelli, P, Doucas, V, Craig, E, 2001

机译：传入的HIV预整合复合物上的INI1和PML的细胞质募集：干扰病毒复制的早期步骤

Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: interference with early steps of viral replication.

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