...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Molecular cell >Cdk1 triggers association of RNA polymerase to cell cycle promoters only after recruitment of the mediator by SBF.
【24h】

Cdk1 triggers association of RNA polymerase to cell cycle promoters only after recruitment of the mediator by SBF.

机译：Cdk1仅在SBF募集介体后才触发RNA聚合酶与细胞周期启动子的缔合。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Activation of HO in yeast involves recruitment of transcription factors in two waves. The first is triggered by inactivation of Cdk1 at the end of mitosis, which promotes import into the nucleus of the Swi5 transcription factor. Swi5 recruits the Swi/Snf chromatin-remodeling complex, which then facilitates recruitment of the SAGA histone acetylase, which in turn permits the binding of the SBF transcription factor. We show here that SBF then recruits the SRB/mediator complex and that this process occurs in the absence of Cdk1 activity. The second wave is triggered by reactivation of Cdk1, which leads to recruitment of PolII, TFIIB, and TFIIH. RNA polymerase is, therefore, recruited to HO in two steps and not as a holoenzyme. A similar sequence of events occurs at other SBF-regulated promoters, such as CLN1, CLN2, and PCL1.
机译：酵母中HO的激活涉及两波中转录因子的募集。第一种是由有丝分裂结束时Cdk1的失活触发的，这促进了Swi5转录因子的核输入。 Swi5募集Swi / Snf染色质重塑复合物，然后促进SAGA组蛋白乙酰化酶的募集，而这又允许SBF转录因子的结合。我们在这里显示SBF然后募集SRB /介体复合体，并且该过程在没有Cdk1活性的情况下发生。第二波由Cdk1的重新激活触发，这导致募集PolII，TFIIB和TFIIH。因此，RNA聚合酶分两步募集到HO中，而不是作为一种全酶。类似的事件序列发生在其他SBF调节的启动子上，例如CLN1，CLN2和PCL1。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号