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首页> 外文期刊>Molecular cell >Generation and interconversion of multiple distinct nucleosomal states as a mechanism for catalyzing chromatin fluidity.
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Generation and interconversion of multiple distinct nucleosomal states as a mechanism for catalyzing chromatin fluidity.

机译：多个不同核小体态的产生和相互转化，作为催化染色质流动性的机制。

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摘要

We have dissected the steps in nucleosome remodeling by BRG1, the ATPase subunit of human SWI/SNF. BRG1-catalyzed DNA exposure is not enhanced by the proximity of the site to the ends of nucleosomal DNA, suggesting that the mechanism involves more than peeling or sliding of the DNA. Comparison of DNA exposure at specific sites with overall changes in the path of DNA implies that BRG1 generates multiple distinct remodeled structures and continuously interconverts them. These characteristics are shared by the entire SWI/SNF complex and have parallels, as well as interesting differences, with the activities of GroEL and Hsp70 protein chaperones. The chaperone-like activity of SWI/SNF is expected to create multiple opportunities for the binding of distinct regulatory factors, providing one mechanism by which SWI/SNF family complexes can contribute to both activation and repression of transcription.
机译：我们已经解剖了BRG1核糖体重塑的步骤，BRG1是人SWI / SNF的ATPase亚基。该位点与核小体DNA末端的接近程度并未增强BRG1催化的DNA暴露，这表明该机制所涉及的不仅仅是DNA的剥离或滑动。将DNA在特定位点的暴露与DNA路径的整体变化进行比较表明，BRG1产生多个不同的重塑结构并不断地相互转化。这些特征由整个SWI / SNF复合体共享，并且与GroEL和Hsp70蛋白伴侣的活性具有相似之处以及有趣的区别。 SWI / SNF的伴侣状活性有望为结合不同的调节因子创造多种机会，从而提供一种机制，SWI / SNF家族复合物可以通过这种机制参与转录的激活和抑制。

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