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首页> 外文期刊>Mycologia >Banana infecting fungus, Fusarium musae, is also an opportunistic human pathogen: Are bananas potential carriers and source of fusariosis?
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Banana infecting fungus, Fusarium musae, is also an opportunistic human pathogen: Are bananas potential carriers and source of fusariosis?

机译：香蕉感染真菌镰刀菌也是一种机会性人类病原体：香蕉是否是潜在的携带者和镰刀菌病的来源？

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摘要

During re-identification of Fusarium strains in the BCCM(TM)/IHEM fungal collection by multilocus sequence-analysis we observed that five strains, previously identified as Fusarium verticillioides, were Fusarium musae, a species described in 2011 from banana fruits. Four strains were isolated from blood samples or biopsies of immune-suppressed patients and one was isolated from the clinical environment, all originating from different hospitals in Belgium or France, 2001-2008. The F. musae identity of our isolates was confirmed by phylogenetic analysis using reference sequences of type material. Absence of the gene cluster necessary for fumonisin biosynthesis, characteristic to F. musae, was also the case for our isolates. In vitro antifungal susceptibility testing revealed no important differences in their susceptibility compared to clinical F. verticillioides strains and terbinafine was the most effective drug. Additional clinical F. musae strains were searched by performing BLAST queries in GenBank. Eight strains were found, of which six were keratitis cases from the U.S. multistate contact lens-associated outbreak in 2005 and 2006. The two other strains were also from the U.S., causing either a skin infection or sinusitis. This report is the first to describe F. musae as causative agent of superficial and opportunistic, disseminated infections in humans. Imported bananas might act as carriers of F. musae spores and be a potential source of infection with F. musae in humans. An alternative hypothesis is that the natural distribution of F. musae is geographically a lot broader than originally suspected and F. musae is present on different plant hosts.
机译：在通过多基因座序列分析对BCCMTM / IHEM真菌收集物中的镰刀菌菌株进行重新鉴定的过程中，我们观察到5种菌株（以前称为镰刀菌Futicium v​​erticillioides）是镰刀菌（Fusarium musae），一种于2011年从香蕉果实中描述的种。从免疫抑制患者的血液样本或活检样本中分离出四种菌株，从临床环境中分离出一种菌株，所有菌株均来自比利时或法国的不同医院，2001-2008年。通过使用类型材料的参考序列进行系统发育分析，确认了我们分离株的穆氏酵母身份。富农菌素生物合成所必需的基因簇的缺失（F. musae的特征）也适用于我们的分离株。体外抗真菌药敏试验显示，与临床F. verticillioides菌株相比，它们的药敏性没有重要差异，特比萘芬是最有效的药物。通过在GenBank中进行BLAST查询来搜索其他临床F. musae菌株。发现了八株，其中六株是在2005年和2006年美国多州角膜接触镜相关疾病暴发中所引起的角膜炎病例。另外两株也来自美国，引起皮肤感染或鼻窦炎。该报告首次描述了家蝇是人类浅表性和机会性传播感染的病原体。进口的香蕉可能充当娘娘腔孢子孢子的携带者，并可能成为人类感染娘娘腔参家族的潜在来源。另一种假设是，家蝇的自然分布在地理上比最初怀疑的要广得多，家蝇存在于不同的植物宿主上。

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