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首页> 外文期刊>Molecular reproduction and development >Regional Development of Uterine Decidualization: Molecular Signaling by Hoxa-10
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Regional Development of Uterine Decidualization: Molecular Signaling by Hoxa-10

机译：子宫蜕膜化的区域发展：Hoxa-10的分子信号。

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摘要

Uterine decidualization, a key event in implantation, is critically controlled by stromal cell proliferation and differentiation Although the molecular mechanism that controls this event is not well understood, the general consensus is that the factors derived locally at the site of implantation influence aspects of decidualization Hoxa-10, a developmentally regulated homeobox transcription factor, is highly expressed in decidualizing stromal cells, and targeted deletion of Hoxa-10 in mice shows severe decidualization defects, primarily due to the reduced stromal cell responsiveness to progesterone (P-4) While the increased stromal cell proliferation is considered to be an initiator of decidualization, the establishment of a full-grown functional decidua appears to depend on the aspects of regional proliferation and differentiation In this regard, this article provides an overview of potential signaling mechanisms mediated by Hoxa-10 that can influence a host of genes and cell functions necessary for propagating regional decidual development
机译：子宫蜕膜化是着床过程中的关键事件，它受基质细胞增殖和分化的严格控制。尽管控制该事件的分子机制尚未广为人知，但普遍的共识是，在着床部位局部衍生的因素会影响蜕膜化的发生。 -10，一种发育受调节的同源盒转录因子，在蜕膜化的基质细胞中高表达，而在小鼠中Hoxa-10的靶向缺失显示出严重的蜕膜化缺陷，这主要是由于基质细胞对孕酮（P-4）的反应性降低所致基质细胞增生被认为是蜕膜化的始作俑者，成熟的功能性蜕膜的建立似乎取决于区域增生和分化的方面。在这方面，本文概述了Hoxa-10介导的潜在信号传导机制。会影响许多基因和细胞功能传播区域蜕变的必要条件

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