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A bioactive (1 -> 3)-, (1 -> 4)-beta-D-glucan from Collybia dryophila and other mushrooms

机译:一种来自Clybia dryophila和其他蘑菇的生物活性(1-> 3)-,(1-> 4)-β-D-葡聚糖

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摘要

Polysaccharides from higher Basidiomycete mushrooms, mainly beta-D-glucans, are considered to be potent bioactive fungal compounds. In this study a beta-glucan (1.237 X 10(6) Da) consisting of (1 -> 3) and (1 -> 4) glucosidic linkages, named Collybia dryophila polysaccharide (CDP), was extracted from the wild mushroom C. dryophila. CDP was shown to strongly inhibit nitric oxide production in activated macrophages suggesting that this polysaccharide displays a potential anti-inflammatory activity. In addition it was shown that polysaccharides similar to CDP (CDP-like) are present in Lentinus edodes and different wild mushrooms collected in northeastern North America.
机译:来自高级担子菌蘑菇的多糖,主要是β-D-葡聚糖,被认为是有效的生物活性真菌化合物。在这项研究中,从野生蘑菇C中提取了一种由(1-> 3)和(1-> 4)糖苷键组成的β-葡聚糖(1.237 X 10(6)Da),其名称为Collybia dryophila polysaccharide(CDP)。干燥。已显示CDP强烈抑制活化巨噬细胞中一氧化氮的产生,表明该多糖具有潜在的抗炎活性。此外,研究表明,香菇和北美东北部采集的不同野生蘑菇中都存在类似于CDP的多糖(类似CDP)。

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