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首页> 外文期刊>Mycologia >Roles of Aspergillus nidulans Cdc42/Rho GTPase regulators in hyphal morphogenesis and development
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Roles of Aspergillus nidulans Cdc42/Rho GTPase regulators in hyphal morphogenesis and development

机译：构巢曲霉Cdc42 / Rho GTPase调节剂在菌丝形态发生和发展中的作用

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摘要

The Rho-related family of GTPases are pivotal regulators of morphogenetic processes in diverse eukaryotic organisms. In the filamentous fungi two related members of this family, Cdc42 and Rac1, perform particularly important roles in the establishment and maintenance of hyphal polarity. The activity of these GTPases is tightly controlled by two sets of regulators: guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Despite the importance of Cdc42 and Rac1 in polarized hyphal growth, the morphogenetic functions of their cognate GEFs and GAPs have not been widely characterized in filamentous fungi outside the Saccharomycotina. Here we present a functional analysis of the Aspergillus nidulans homologs of the yeast GEF Cdc24 and the yeast GAP Rga1. We show that Cdc24 is required for the establishment of hyphal polarity and localizes to hyphal tips. We also show that Rga1 is necessary for the suppression of branching in developing conidiophores. During asexual development Rga1 appears to act primarily via Cdc42 and in doing so serves as a critical determinant of conidiophore architecture. Our results provide new insight into the roles of Cdc42 during development in A. nidulans.
机译：Rho相关的GTPases家族是各种真核生物中形态发生过程的关键调节因子。在丝状真菌中，该家族的两个相关成员Cdc42和Rac1在菌丝极性的建立和维持中起着特别重要的作用。这些GTPases的活性受到两组调节剂的严格控制：鸟嘌呤核苷酸交换因子（GEF）和GTPase激活蛋白（GAP）。尽管Cdc42和Rac1在极化的菌丝生长中很重要，但它们的同源GEFs和GAPs的形态发生功能尚未在酿酒酵母以外的丝状真菌中得到广泛表征。在这里，我们介绍了酵母GEF Cdc24和酵母GAP Rga1的构巢曲霉的功能分析。我们表明，Cdc24是建立菌丝极性所必需的，并且位于菌丝尖端。我们还表明，Rga1是抑制发展分生孢子的分支所必需的。在无性发育过程中，Rga1似乎主要通过Cdc42起作用，并且在这种情况下是子叶虫结构的关键决定因素。我们的结果提供了新的洞察力，在C.42在构巢曲霉的发展过程中的作用。

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