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首页> 外文期刊>Molecular cell >The Mouse RecA-like Gene Dmc1 Is Required for Homologous Chromosome Synapsis during Meiosis
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The Mouse RecA-like Gene Dmc1 Is Required for Homologous Chromosome Synapsis during Meiosis

机译：小鼠RecA样基因Dmc1是减数分裂过程中同源染色体突触所必需的

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摘要

The mouse Dmc1 gene is an E. coli RecA homolog that is specifically expressed in meiosis. The DMC1 protein was detected in leptotene-to-zygotene spermatocytes, when homology pairing likely initiates. Targeted gene disruption in the male mouse showed an arrest of meiosis of germ cells at the early zygotene stage, followed by apoptosis. In female mice lacking the Dmc1 gene, normal differentiation of oogenesis was aborted in embryos, and germ cells disappeared in the adult ovary. Meiotic chromosome analysis of Dmc1-deficient mouse spermatocytes revealed random spread of univalent axial elements without correct pairing between homologs. In rare cases, however, we observed complex pairing among nonhomologs. Thus, the Mouse Dmc1 gene is required for homologous synapsis of chromosomes in meiosis.
机译：小鼠Dmc1基因是在减数分裂中特异性表达的大肠杆菌RecA同源物。当同源配对可能启动时，在瘦素至合子精子细胞中检测到DMC1蛋白。雄性小鼠中的靶向基因破坏表明，在合子早期，生殖细胞的减数分裂被阻止，随后发生凋亡。在缺乏Dmc1基因的雌性小鼠中，胚胎发生正常的卵子分化，而成年卵巢中的生殖细胞消失了。 Dmc1缺陷小鼠精母细胞的减数分裂染色体分析显示，单价轴向元素的随机扩散，同源物之间没有正确的配对。但是，在极少数情况下，我们观察到非同源物之间存在复杂的配对。因此，Mouse Dmc1基因是减数分裂中染色体同源突触所必需的。

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