TAP, the Human Homolog of Mex67p, Mediates CTE-Dependent RNA Export from the Nucleus

Patric Gruter; Carlos Tabernero; Cayetano von Kobbe; Christel Schmitt; Claudio Saavedra; Angela Bachi; Matthias Wilm; Barbara K. Felber; Elisa Izaurralde

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TAP, the Human Homolog of Mex67p, Mediates CTE-Dependent RNA Export from the Nucleus

机译：TAP，Mex67p的人类同源物，介导CTE依赖的核从核中输出。

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The Constitutive transport element (CTE) of the type D retroviruses promotes nuclear export of unspliced viral RNAs apparently by recruiting host factor(s) required for export of cellular messenger RNAs. Here, we report the identification of TAP as the cellular factor that specifically binds to wild-type CTE but not to export-deficient CTE mutants. Microinjection experiments performed in Xenopus oocytes demonstrate that TAP directly stimulates CTE-dependent export. Furthermore, TAP overcomes the mRNA export block caused by the presence of saturating amounts of CTE RNA. Thus, TAP, like its yeast homolog Mex67p, is a bona fide mRNA nuclear export mediator. TAP is the second cellular RNA binding protein shown to be directly involved in the export of its target RNA.

机译：D型逆转录病毒的本构转运元件（CTE）显然通过募集细胞信使RNA出口所需的宿主因子来促进未剪接病毒RNA的核出口。在这里，我们报告的TAP的鉴定为细胞因子，其特异性结合野生型CTE，但不结合出口缺陷型CTE突变体。在非洲爪蟾卵母细胞中进行的显微注射实验表明，TAP直接刺激CTE依赖性出口。此外，TAP克服了饱和CTE RNA的存在引起的mRNA输出阻滞。因此，TAP与其酵母同系物Mex67p一样，是真正的mRNA核输出介体。 TAP是第二种细胞RNA结合蛋白，显示直接参与其靶RNA的输出。

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《Molecular cell》 |1998年第5期|共11页
作者
Patric Gruter; Carlos Tabernero; Cayetano von Kobbe; Christel Schmitt; Claudio Saavedra; Angela Bachi; Matthias Wilm; Barbara K. Felber; Elisa Izaurralde;
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中图分类分子生物学;细胞生物学;
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1. TAP, the Human Homolog of Mex67p, Mediates CTE-Dependent RNA Export from the Nucleus [J] . Patric Gruter, Carlos Tabernero, Cayetano von Kobbe, Molecular cell . 1998,第5期

机译：TAP，Mex67p的人类同源物，介导CTE依赖的核从核中输出。
2. Mex67p of Schizosaccharomyces pombeInteracts with Rae1p in Mediating mRNA Export [J] . Jin Ho Yoon, Dona C. Love, Anjan Guhathakurta, Molecular and Cellular Biology . 2000,第23期

机译：粟酒裂殖酵母Mex67p与Rae1p相互作用介导mRNA出口。
3. The mRNA export in Caenorhabditis elegans is mediated by Ce-NXF-1, an ortholog of human TAP/NXF and Saccharomyces cerevisiae Mex67p. [J] . Tan W, Zolotukhin AS, Bear J, RNA . 2000,第12期

机译：秀丽隐杆线虫的mRNA出口由人类TAP / NXF和酿酒酵母Mex67p的直系同源物Ce-NXF-1介导。
4. Cdc48, the homolog of mammalian p97, mediates aggresomal deposits in yeast PolyQ model. [C] . Yan Wang, Giuseppe Infusini, Anatoli B. Meriin, ASMS Conference on Mass Spectrometry and Allied Topics . 2007

机译：CDC48，哺乳动物P97的同源物，介导酵母PolyQ模型中的胃癌沉积物。
5. Characterization of the A. thaliana cytoplasmic tRNA export protein (CTEXP) and investigation of retrograde tRNA movement to the nucleus in plant cells. [D] . Johnstone, Aaron. 2010

机译：拟南芥胞质tRNA输出蛋白（CTEXP）的特征以及逆转录tRNA向植物细胞内核运动的研究。
6. TAP binds to the constitutive transport element (CTE) through a novel RNA-binding motif that is sufficient to promote CTE-dependent RNA export from the nucleus. [O] . I C Braun, E Rohrbach, C Schmitt, 1999

机译：TAP通过足以促进CTE依赖性RNA从细胞核输出的新型RNA结合基序与组成型转运元件（CTE）结合。
7. TAP binds to the constitutive transport element (CTE) through a novel RNA-binding motif that is sufficient to promote CTE-dependent RNA export from the nucleus [O] . I. C. Braun 1999

机译：通过新的RNA结合基质点击与本构体传输元件（CTE）结合，足以促进从细胞核的CTE依赖性RNA导出

TAP, the Human Homolog of Mex67p, Mediates CTE-Dependent RNA Export from the Nucleus

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