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首页> 外文期刊>Cancer: A Journal of the American Cancer Society >CK19 and CD10 Expression in Pancreatic Neuroendocrine Tumors Diagnosed by Endoscopic Ultrasound-Guided Fine-Needle Aspiration Cytology
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CK19 and CD10 Expression in Pancreatic Neuroendocrine Tumors Diagnosed by Endoscopic Ultrasound-Guided Fine-Needle Aspiration Cytology

机译：内镜超声引导下细针穿刺细胞学诊断胰腺神经内分泌肿瘤中CK19和CD10的表达

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BACKGROUND: CK19 and CD10 are useful markers in the differential diagnosis of pancreatic tumors. The authors evaluated CK19 and CD10 expression in pancreatic neuroendocrine tumors (NETs) obtained by endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA). METHODS: Twenty-eight patients diagnosed with pancreatic NETs based on EUS-FNA cytology were studied retrospectively (2004-2007) for immunohistochemical expression of CK19 and CD10. Immunohistochemistry was performed on cell blocks for each case. The pattern of expression for CD10 (cytoplasmic or membranous) and its intensity (0-2) were noted. The staining of the stromal elements for CD10 was recorded as negative. Cytoplasmic staining in tumor cells and percentage distribution (1+ to 4+) for CK19 were regarded as positive. RESULTS: Twenty-three of 28 (82.14%) NETs showed positive cytoplasmic and/or membranous staining for CD10, and 25 of 28 (89.29%) cases were positive for CK19. CONCLUSIONS: The findings demonstrate the high expression of CD10 and CK19 in pancreatic NETs. This indicates that CD10 and CK19 cannot reliably differentiate NETs from other tumors with similar cytomorphologic features (solid pseudopapillary tumors, which frequently stain with CD10, and pancreatic adenocarcinoma, which stains with CK19).
机译：背景：CK19和CD10在胰腺肿瘤的鉴别诊断中是有用的标志物。作者评估了内镜超声（EUS）引导的细针穿刺术（FNA）获得的胰腺神经内分泌肿瘤（NETs）中CK19和CD10的表达。方法：回顾性分析2004年至2007年根据EUS-FNA细胞学诊断为胰腺NETs的28例患者的CK19和CD10的免疫组织化学表达。在每种情况下，在细胞块上进行免疫组织化学。记录了CD10（细胞质或膜性）的表达模式及其强度（0-2）。 CD10的基质元素染色被记录为阴性。肿瘤细胞的细胞质染色和CK19的百分比分布（1+至4+）被视为阳性。结果：28例中有23例（82.14％）NETs显示CD10细胞质和/或膜性染色阳性，而28例中有25例（89.29％）CK19阳性。结论：研究结果表明CD10和CK19在胰腺网中高表达。这表明CD10和CK19无法将NETs与其他具有类似细胞形态特征的肿瘤（实体假乳头状瘤，经常被CD10染色，以及胰腺腺癌，被CK19染色）可靠地区分开。

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