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首页> 外文期刊>Cancer: A Journal of the American Cancer Society >Fine-needle aspiration of intrapancreatic accessory spleen: cytomorphologic features and differential diagnosis.
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Fine-needle aspiration of intrapancreatic accessory spleen: cytomorphologic features and differential diagnosis.

机译：胰内副脾的细针穿刺：细胞形态学特征和鉴别诊断。

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摘要

Intrapancreatic accessory spleen (IPAS) is a rare benign lesion of the pancreas that frequently clinically and radiographically mimics a solid neoplasm. Very rarely, epidermoid cysts may form in IPAS and be mistaken for a cystic neoplasm of the pancreas on radiographic imaging. IPAS and epidermoid cyst involving intrapancreatic cyst (ECIPAS) are benign, and, if recognized, do not require surgical intervention. There are few reports of the cytopathologic features of IPAS diagnosed by fine-needle aspiration (FNA).Here we report a series of 6 cases of endoscopic ultrasound (EUS)-guided FNA of IPAS, 3 of which had histological confirmation, including 1 case of histologically confirmed ECIPAS.Cytomorphologic features of IPAS include a polymorphous population of hematopoietic cells, including lymphocytes, eosinophils, histiocytes, plasma cells, and red blood cells, admixed with numerous small blood vessels representing splenic sinusoids. CD8 immunostaining of cell block or core biopsy material highlights splenic endothelial cells and confirms the diagnosis. FNA of ECIPAS reveals predominantly macrophages and proteinaceous debris.Diagnostic pitfalls include pancreatic neuroendocrine tumor. If IPAS is recognized as a diagnostic consideration on EUS-FNA, unnecessary surgical resection may be avoided.
机译：胰内辅助脾（IPAS）是一种罕见的胰腺良性病变，在临床和放射学上经常模仿实体瘤。在极少见的情况下，表皮样囊肿可能在IPAS中形成，并在影像学成像中被误认为是胰腺的囊性肿瘤。 IPAS和累及胰腺内囊肿的表皮样囊肿（ECIPAS）是良性的，并且，如果被识别，则不需要手术干预。细针穿刺（FNA）诊断IPAS的细胞病理学特征的报道很少，这里我们报道了6例经内镜超声引导的IPAS FNA的病例，其中3例经组织学证实，其中1例IPAS的组织形态学特征包括造血细胞的多态群体，包括淋巴细胞，嗜酸性粒细胞，组织细胞，浆细胞和红细胞，并与代表脾窦的众多小血管混合。细胞块或核心活检材料的CD8免疫染色突出了脾内皮细胞并证实了诊断。 ECIPAS的FNA主要显示巨噬细胞和蛋白质碎片。诊断缺陷包括胰腺神经内分泌肿瘤。如果IPAS被认为是EUS-FNA的诊断考虑因素，则可以避免不必要的手术切除。

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