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首页> 外文期刊>Moscow university biological sciences bulletin >Effects of Diadenosine Polyphosphates on Inward Rectifiei Potassium Currents in Rat Cardiomyocytes
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Effects of Diadenosine Polyphosphates on Inward Rectifiei Potassium Currents in Rat Cardiomyocytes

机译：二磷酸腺苷对大鼠心肌细胞内向整流钾电流的影响

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摘要

Diadenosine polyphosphates are now considered a novel class of endogenous paracrine signal compounds. The putative role of these compounds in pathogenesis of myocardial infarction was proposed, since the concentration of diadenosine polyphosphates increases in the cardiac tissue following the ischemic lesion and myocardial necrosis. Therefore, possible effects of diadenosine polyphosphates on cardiac electrical activity and their ionic mechanisms are of considerable interest.In the present study, we have investigated the effects of diadenosine pentaphosphate (Ap5A), diadenosine tet-raphosphate (Ap4A), and NAD+ on transmembrane currents belonging to the family of potassium inward rectifiers: background inward rectifier (lKi),ATP-dependent potassium current (1katp)> and acetylcholine-dependent current (Ikacii)- Experiments were performed using the whole-cell patch-clamp technique on isolated atrial and ventricular rat cardiomyocytes. We have demonstrated that none of the tested adenine compounds affects l_(K) and Ikacii- Ap5A (lO--1 M) induces considerable decrease of both inward and outward component of I_(KAT)> by 22.1 and 19% of control value, respectively. Higher concentration of Ap5A (3 x 10 5 M) induces stronger suppression of IKAn>—by 47.5% and 37.8%, respectively. However, IKATP was found to be insensitive to Ap4A and NAD+.
机译：腺苷多磷酸盐现在被认为是一类新型的内源性旁分泌信号化合物。提出了这些化合物在心肌梗死发病机理中的假定作用，因为在缺血性病变和心肌坏死后心脏组织中二磷酸腺苷多磷酸的浓度增加。因此，磷酸腺苷多磷酸对心脏电活动的可能影响及其离子机制备受关注。在本研究中，我们研究了磷酸五磷酸腺苷（Ap5A），四磷酸腺苷四磷酸腺苷（Ap4A）和NAD +对跨膜电流的影响。属于钾内向整流器家族：背景内向整流器（lKi），ATP依赖性钾电流（1katp）>和乙酰胆碱依赖性电流（Ikacii）-使用全细胞膜片钳技术对孤立的心房和心室大鼠心肌细胞。我们已经证明，测试的腺嘌呤化合物均不影响I_（K），Ikacii-Ap5A（10--1 M）诱导I_（KAT）的内向和外向成分均显着降低22.1和对照值的19％，分别。 Ap5A（3 x 10 5 M）的浓度越高，对IKAn>的抑制作用就越强，分别为47.5％和37.8％。但是，发现IKATP对Ap4A和NAD +不敏感。

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