Efficient Synthesis of Fused Oxazepino-isoquinoline Scaffolds via an Ugi, Followed by an Intramolecular Cyclization

Li Yong; Meng Jiang-Ping; Lei JieChen Zhong-ZhuTang Dian-YongZhu JinZhang JinXu Zhi-Gang

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Efficient Synthesis of Fused Oxazepino-isoquinoline Scaffolds via an Ugi, Followed by an Intramolecular Cyclization

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A mild and efficient protocol was developed for the synthesis of oxazepino-isoquinolines via a one-pot Ugi four-component reaction, followed by the intramolecular addition of the resulting alcohol to an alkyne moiety under microwave irradiation conditions. Notably, this process only required one purification step, providing facile access to two series of complex and potentially interesting biologically active scaffolds.

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《ACS combinatorial science》 |2017年第5期|324-330|共7页
作者
Li Yong; Meng Jiang-Ping; Lei JieChen Zhong-ZhuTang Dian-YongZhu JinZhang JinXu Zhi-Gang;
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作者单位

Chongqing Univ Arts & Sci, Chongqing Engn Lab Targeted & Innovat Therapeut, Chongqing Key Lab Kinase Modulators Innovat Med, IATTI, 319 Honghe Ave, Chongqing 402160, Peoples R China;

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正文语种英语
中图分类化学;
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oxazepino-isoquinoline; Ugi reaction; multicomponent reactions; alcohol addition; hydroxyisoquinolines;

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1. ChemInform Abstract: Solid Phase Synthesis of Fused Bicyclic Amino Acid Derivatives via Intramolecular Pauson‐Khand Cyclization: Versatile Scaffolds for Combinatorial Chemistry. [J] . G. L. BOLTON, J. C. HODGES, J. R. RUBIN Chem Inform . 1997,第38期

机译：ChemInform Abstract: Solid Phase Synthesis of Fused Bicyclic Amino Acid Derivatives via Intramolecular Pauson‐Khand Cyclization: Versatile Scaffolds for Combinatorial Chemistry.
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机译：PIFA-promoted intramolecular oxidative cyclization of pyrrolo- and indolo1,2-aquinoxalino-appended porphyrins: an efficient synthesis of meso,β-pyrrolo- and indolo1,2-aquinoxalino-fused porphyrins
3. ChemInform Abstract: Efficient Strategy for the Iterative Synthesis of trans‐Fused Polycyclic Ether via SmI2‐Induced Reductive Intramolecular Cyclization. [J] . Nobuyuki Hori, Hiroko Matsukura, Goh MatsuoTadashi Nakata Chem Inform . 2002,第30期

机译：ChemInform Abstract: Efficient Strategy for the Iterative Synthesis of trans‐Fused Polycyclic Ether via SmI2‐Induced Reductive Intramolecular Cyclization.
4. Synthesis, clathrate inclusion properties and racemization studies of Benzo-fused tetraphenylenes. [O] . 1988

机译：synthesis, clathrate inclusion properties and racemization studies of Benzo-fused tetraphenylenes.

Efficient Synthesis of Fused Oxazepino-isoquinoline Scaffolds via an Ugi, Followed by an Intramolecular Cyclization

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