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首页> 外文期刊>Korean Journal of Microbiology and Biotechnology >Antimicrobial Peptides Derived from the Marine Organism(s) and Its Mode of Action
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Antimicrobial Peptides Derived from the Marine Organism(s) and Its Mode of Action

机译：源自海洋生物的抗菌肽及其作用方式

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摘要

Recently, marine organisms are emerging as a leading group for identifying and extracting novel bioactive substances. These substances are known to possess a potential regarding not only as a source of pharmaceutical products but also their beneficialeffects on humans. Among the substances, antimicrobial peptides (AMPs) specifically have attracted considerable interest for possible use in the development of new antibiotics. AMPs are characterized by relatively short cationic peptides containing theability to adopt a structure in which cationic or hydrophobic amino acids are spatially scattered. Although a few reports address novel marine organisms-derived AMPs, their antimicrobial mechanism^) are still remain unknown. In this review, we summarizedthe peptides previously investigated, such as Pleurocidin, Urechistachykinins, Piscidins and Arenicin-1. These peptides exhibited significant antimicrobial activities against human microbial pathogens without remarkable hemolytic effects against human erythrocytes, and their mode of actions are based on permeabilization of the plasma membrane of the pathogen. Therefore, the study of antimicrobial peptides derived from marine organisms may prove to be useful in the design of future therapeutic antimicrobial drugs.
机译：最近，海洋生物正在成为鉴定和提取新型生物活性物质的领导小组。已知这些物质不仅具有作为药物产品来源的潜力，而且还具有对人体的有益作用。在这些物质中，抗菌肽（AMPs）特别引起了人们极大的兴趣，可能用于开发新的抗生素。 AMPs的特征是相对较短的阳离子肽，其具有能够采用其中阳离子或疏水氨基酸在空间上分散的结构的能力。尽管有一些报道涉及新型海洋生物来源的AMP，但其抗菌机制仍然未知。在这篇综述中，我们总结了先前研究的肽，如Pleurocidin，Urechistachykinins，Piscidins和Arenicin-1。这些肽对人类微生物病原体显示出显着的抗菌活性，而对人类红细胞没有显着的溶血作用，其作用方式基于病原体质膜的透化作用。因此，对源自海洋生物的抗菌肽的研究可能被证明可用于未来治疗性抗菌药物的设计。

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