Dynamics of Antibody Nuclease Activity in Blood of Women during Pregnancy and Lactation

V.N.Buneva; A.N.Kudryavtseva; A.V.Galvita; V.V.Dubrovskaya; O.V.Khokhlova; I.A.Kalinina; V.A.Galenok; G.A.Nevinsky

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Dynamics of Antibody Nuclease Activity in Blood of Women during Pregnancy and Lactation

机译：妊娠和哺乳期妇女血液中抗体核酸酶活性的动态

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In human milk we previously found catalytic antibodies(abzymes)catalyzing hydrolysis of NDA,RNA,NMP,NDP,and NTP and also phosphorylation of proteins and lipids.In the present study we have analyzed nuclease activities of antibodies in blood of women during pregnancy and lactation.Blood of healthy male and female volunteers lacked catalytically active antibodies,whereas antibodies from blood of pregnant women hydrolyzed DNA and RNA and their relative activity varied over a wide range.Relative blood abzyme activities significantly increased after delivery and at the beginning of lactation.The highest abzyme activity was observed in blood of parturient women.Although the dynamics of changes in antibody Dnase activity during pregnancy was rather individual for each woman,there was a common trend in the increase in antibody activity in the first and/or third trimester of the pregnancy.The Dnase activity of IgG and IgM form blood of healthy pregnant women was 4-5 times less than that from pregnant women with pronounced autoimmune thyroiditis.

机译：在人乳中，我们先前发现了催化抗体（酶）催化NDA，RNA，NMP，NDP和NTP的水解以及蛋白质和脂质的磷酸化。在本研究中，我们分析了孕妇和孕妇血液中抗体的核酸酶活性。健康的男性和女性志愿者的血液中缺乏催化活性抗体，而孕妇血液中的抗体会水解DNA和RNA，并且其相对活性在很宽的范围内变化。分娩后和哺乳初期相对的血液酶活性明显增加。在产妇的血液中观察到最高的抗体酶活性。尽管每个妇女的妊娠期间抗体Dnase活性变化的动力学相当个别，但在孕妇的头三个月和/或三个月中，抗体活性增加是一个普遍趋势。健康孕妇血液中的IgG和IgM的DNase活性比正常孕妇低4-5倍患有明显的自身免疫性甲状腺炎的女性。

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《Biochemistry》 |2003年第8期|共11页
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V.N.Buneva; A.N.Kudryavtseva; A.V.Galvita; V.V.Dubrovskaya; O.V.Khokhlova; I.A.Kalinina; V.A.Galenok; G.A.Nevinsky;
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正文语种 eng
中图分类生物化学;
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human milk and blood; pregnancy and lactation; immunoglobulins; natural abzymes; hydrolysis of dna and rna;

机译：人乳和血液;怀孕和哺乳;免疫球蛋白;天然抗体;脱氧核糖核酸和核糖核酸的水解;

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1. Dynamics of Antibody Nuclease Activity in Blood of Women during Pregnancy and Lactation [J] . V.N.Buneva, A.N.Kudryavtseva, A.V.Galvita, Biochemistry . 2003,第8期

机译：妊娠和哺乳期妇女血液中抗体核酸酶活性的动态
2. Genome-wide DNA-methylation is associated with pregnancy and lactation and mediated by changes in blood cell composition in young Filipino women [J] . Ryan C. P., Jones M. J., Kobor M. S., American journal of human biology: the official journal of the Human Biology Council . 2018,第2期

机译：基因组 - 宽的DNA-甲基化与妊娠和哺乳期有关，并通过年轻菲律宾女性的血细胞组合物的变化介导
3. Circadian Dynamics of Monocyte Phagocytic Activity in Women during Lactation Complicated by Iron Deficiency. [J] . Barkova EN, Nazarenko EV Bulletin of experimental biology and medicine . 2005,第1期

机译：哺乳期妇女缺铁导致的单核细胞吞噬活动的昼夜节律动态。
4. Rapid and Sensitive Detection of HSV in pregnant Women During Pregnancy and Before Labor By Direct Fluorescent Assay (DFA) with Monoclonal Antibodies [C] . M. Askienazy-Elbhar, M. Azoulay International Multidisciplinary Congress . 2003

机译：用单克隆抗体直接荧光测定（DFA）在妊娠期间和劳动前的孕妇HSV快速敏感
5. PROLACTIN IN SERUM AND MILK DURING NORMAL PREGNANCY AND LACTATION AND HORMONALLY INDUCED LACTATION [D] . SALAH, MAHMOUD SAYED-AHMED. 1982

机译：正常妊娠和哺乳期及激素诱导的哺乳期血清和牛奶中的催乳激素
6. Monoclonal antibody treatment during pregnancy and/or lactation in women with MS or neuromyelitis optica spectrum disorder [O] . Andrea Ines Ciplea, Annette Langer-Gould, Annick de Vries, 2020

机译：患有MS或视神经脊髓炎频谱障碍的女性在妊娠和/或哺乳期间的单克隆抗体治疗
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Dynamics of Antibody Nuclease Activity in Blood of Women during Pregnancy and Lactation

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