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Columnar DNA Superlattices in Lamellar o-Ethylphosphatidylcholine Lipoplexes:Mechanism of the Gel-Liquid Crystalline Lipid Phase Transition

机译:层状o-乙基磷脂酰胆碱脂复合物中的柱状DNA超晶格:凝胶-液体结晶脂质相变的机制。

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摘要

DNA arranges into rectangular columnar superlattices between interdigitated lipid bilayers in the low-temperature gel phase of the lipoplexes of the cationic o-ethylphosphatidylcholines.The interlamellar correlation in the DNA ordering is not observed within the liquid crystalline lipid phase.The gel-liquid crystalline phase transition of the lipid induces a contraction of the DNA smectic array that matches the increased positive charge density of the membrane surface caused by the interdigitated-noninterdigitated transition.The transition proceeds via an intermediate state that has an expanded lamellar repeat period.
机译:在阳离子o-乙基磷脂酰胆碱脂复合物的低温凝胶相中,DNA在相互交叉的脂双层之间排列成矩形柱状超晶格,在液晶脂相中未观察到DNA层间的相关性。脂质的过渡诱导DNA近晶阵列的收缩,该收缩与由叉指-非叉指的过渡引起的膜表面正电荷密度的增加相匹配。过渡通过具有扩展的层状重复周期的中间状态进行。

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