• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nano letters >Direct confinement of individual viruses within polyethylene glycol (PEG) nanowells
【24h】

Direct confinement of individual viruses within polyethylene glycol (PEG) nanowells

机译：直接将单个病毒限制在聚乙二醇（PEG）纳米孔中

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Individual M13 viruses were spatially confined within wells fabricated from nanomolding of a PEG-based random copolymer. The viruses were selectively adhered to the region pretreated with an antibody against the virus, resulting in individual virus arrays. The polymer surface was found to be highly resistant to the attachment of the virus (similar to 0.02 mu m(-2)), approximately 2 orders of magnitude lower than that on a bare silicon surface. The physical height of the template provided an additional barrier to the attachment of the virus due to entropic penalty in bending of a semi-flexible M13 virus. The effects of pattern size and barrier height were investigated, revealing that a certain critical height is needed to ensure successful confinement within the template for a given pattern size.
机译：单个M13病毒在空间上限制在由基于PEG的无规共聚物的纳米成型制成的孔中。将病毒选择性地粘附到用抗病毒抗体预处理的区域上，从而形成单个病毒阵列。发现聚合物表面对病毒的附着具有很高的抵抗力（类似于0.02μm（-2）），比裸露的硅表面低约2个数量级。模板的物理高度由于半柔性M13病毒弯曲时的熵损失而为病毒的附着提供了额外的障碍。研究了图案大小和势垒高度的影响，发现对于给定图案大小，需要一定的临界高度来确保成功限制模板在模板中的尺寸。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号