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Multisegment nanowire sensors for the detection of DNA molecules

机译:用于检测DNA分子的多段纳米线传感器

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摘要

We describe a novel application for detecting specific single strand DNA sequences using multisegment nanowires via a straightforward surface functionalization method. Nanowires comprising CdTe-Au-CdTe segments are fabricated using electrochemical deposition, and electrical characterization indicates a p-type behavior for the multisegment nanostructures, in a back-to-back Schottky diode configuration. Such nanostructures modified with thiol-terminated probe DNA fragments could function as high fidelity sensors for biomolecules at very low concentration. The gold segment is utilized for functionalization and binding of single strand DNA (ssDNA) fragments while the CdTe segments at both ends serve to modulate the equilibrium Fermi level of the heterojunction device upon hybridization of the complementary DNA fragments (cDNA) to the ssDNA over the Au segment. Employing such multisegment nanowires could lead to the fabrication more sophisticated and high multispecificity biosensors via selective functionalization of individual segments for biowarfare sensing and medical diagnostics applications.
机译:我们描述了一种新颖的应用,用于通过直接的表面功能化方法使用多段纳米线检测特定的单链DNA序列。使用电化学沉积法制备包含CdTe-Au-CdTe链段的纳米线,电特性表明背对背的肖特基二极管配置中的多段纳米结构具有p型行为。用巯基封端的探针DNA片段修饰的此类纳米结构可以在非常低的浓度下充当生物分子的高保真传感器。金链段用于单链DNA(ssDNA)片段的功能化和结合,而两端的CdTe链段则在互补DNA片段(cDNA)与ssDNA杂交后,用于调节异质结器件的平衡费米能级。金段。通过针对生物战感测和医学诊断应用的各个片段的选择性功能化,采用此类多片段纳米线可导致制造更复杂和更高多特异性的生物传感器。

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