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Viral nanoparticles donning a paramagnetic coat: Conjugation of MRI contrast agents to the MS2 capsid

机译:穿顺磁性涂层的病毒纳米颗粒:MRI造影剂与MS2衣壳的结合

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摘要

A nanoparticle magnetic resonance imaging (MRI) contrast agent was developed by conjugation of more than 500 gadolinium chelate groups onto a viral capsid. The high density of paramagnetic centers and slow tumbling rate of modified MS2 capsids provided enhanced T-1 relaxivities up to 7200 mM(-1) s(-1) per particle. A bimodal imaging agent was generated by sequential conjugation of fluorescein and Gd3+ chelate. These results illustrate the potential for engineering natural protein assemblies to address bionanotechnology applications.
机译:通过将超过500个g螯合物基团缀合到病毒衣壳上,开发了纳米粒子磁共振成像(MRI)造影剂。顺磁中心的高密度和修饰的MS2衣壳的慢翻滚速率提供了增强的T-1弛豫性,每个粒子最高可达7200 mM(-1)s(-1)。通过荧光素和Gd3 +螯合物的顺序缀合生成双峰显像剂。这些结果说明了工程化天然蛋白装配体以解决生物纳米技术应用的潜力。

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