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Core-like particles of an enveloped animal virus can self-assemble efficiently on artificial templates

机译：包膜动物病毒的核样颗粒可以在人工模板上高效自组装

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摘要

Alphaviruses are animal viruses holding great promise for biomedical applications as drug delivery vectors, functional imaging probes, and nanoparticle delivery vesicles because of their efficient in vitro self-assembly properties. However, due to their complex structure, with a protein capsid encapsulating the genome and an outer membrane composed of lipids and glycoproteins, the in-vitro self-assembly of virus-like particles, which have the functional virus coat but carry an artificial cargo, can be challenging. Fabrication of such alphavirus-like particles is likely to require a two-step process: first, the assembly of a capsid structure around an artificial core, second the addition of the membrane layer. Here we report progress made on the first step: the efficient self-assembly of the alphavirus capsid around a functionalized nanoparticle core.
机译：甲病毒是动物病毒，因为它们具有高效的体外自组装特性，因此在生物医学中作为药物传递载体，功能性成像探针和纳米颗粒传递囊泡具有广阔的前景。但是，由于其结构复杂，蛋白质衣壳包裹了基因组，而外膜则由脂质和糖蛋白组成，因此病毒样颗粒的体外自组装具有病毒功能，但携带人工货物，可能具有挑战性。制备这种甲病毒样颗粒可能需要两步过程：首先，围绕人工核心组装衣壳结构，其次，增加膜层。在这里，我们报告了第一步的进展：围绕功能化纳米颗粒核心的甲病毒衣壳的高效自组装。

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