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Short Forms of Membrane Receptors:Generation and Role in Hormonal Signal Transduction

机译:膜受体的短形式:激素信号转导的产生和作用。

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摘要

This review highlights the generation of various types of short forms of membrane hormonal receptors and the mode of regulation of their tissue-specific patterns.The short forms of membrane receptors are classified on the basis of localization of missing functional fragments.The review provides examples of tissues for which expression of short forms may serve as a marker of changes of ontogenetic stage,physiological state,or the development of pathological process.The short forms of receptors are shown to participate in determining tissue-specificity and efficacy of hormonal signal transduction,as well as in transport of hormones within cell,through physiological barriers,and in blood circulation.Peculiarities of signal transduction pathways for short receptor forms and potential physiological significance of these forms are analyzed.It is concluded that the ratio of long and short receptor forms may serve as a key marker of dynamic changes of differentiation stage and alterations of metabolic and proliferative activity of tissues under normal and pathologic conditions,and thus to be an important indicator of therapeutic effect for many pathological processes.
机译:这篇综述着重介绍了各种类型的短膜激素受体的产生及其对组织特异性模式的调节模式,这些短膜受体是根据缺失的功能性片段的定位进行分类的。表达短形式的组织可以作为个体发生阶段,生理状态或病理过程发展的标志。显示短形式的受体参与确定激素信号转导的组织特异性和功效,如分析了短受体形式的信号转导途径的特殊性以及这些形式的潜在生理学意义。充当分化阶段动态变化和m变化的关键标志在正常和病理条件下组织的代谢和增生活性,因此成为许多病理过程治疗效果的重要指标。

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