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Self-assembled virus-like particles with magnetic cores

机译:具有磁芯的自组装病毒样颗粒

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Efficient encapsulation of functionalized spherical nanoparticles by viral protein cages was found to occur even if the nanoparticle is larger than the inner cavity of the native capsid. This result raises the intriguing possibility of reprogramming the self-assembly of viral structural proteins. The iron oxide nanotemplates used in this work are superparamagnetic, with a blocking temperature of about 250 K, making these virus-like particles interesting for applications such as magnetic resonance imaging and biomagnetic materials. Another novel feature of the virus-like particle assembly described in this work is the use of an anionic lipid micelle coat instead of a molecular layer covalently bound to the inorganic nanotemplate. Differences between the two functionalization strategies are discussed.
机译:发现即使病毒颗粒比天然衣壳的内腔大,也可以通过病毒蛋白笼罩有效包裹球形纳米颗粒。该结果提出了重新编程病毒结构蛋白的自组装的有趣的可能性。这项工作中使用的氧化铁纳米模板是超顺磁性的,具有约250 K的阻断温度,使这些病毒样颗粒对于诸如磁共振成像和生物磁性材料的应用很有趣。在这项工作中描述的病毒样颗粒集合体的另一个新颖特征是使用阴离子脂质胶束涂层,而不是与无机纳米模板共价结合的分子层。讨论了两种功能化策略之间的差异。

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