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Nanostructured tantala as a template for enhanced osseointegration

机译:纳米结构的塔塔拉(Tantala)作为增强骨整合的模板

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摘要

The goal of current dental and orthopedic biomaterials research is to design implants that induce controlled and guided tissue growth, and rapid healing. In addition to acceleration of normal wound healing phenomena, these implants should result in the formation of a characteristic interfacial layer with adequate biomechanical properties. To achieve these goals, however, a better understanding of events at the bone-material interface is needed, as well as the development of new materials and approaches that promote osseointegration. Here we present novel nanostructured nanoarrays from tantala that can promote cell adhesion and differentiation. Our results suggest that tantala nanotube arrays enhance osteoblast cell adhesion, proliferation and differentiation. The routes of fabrication of tantala nanotube arrays are flexible and cost-effective, enabling realization of desired platform topologies on existing non-planar orthopedic implants.
机译:当前牙科和整形外科生物材料研究的目标是设计诱导受控和引导的组织生长以及快速愈合的植入物。除了促进正常伤口愈合现象外,这些植入物还应导致形成具有足够生物力学特性的特征性界面层。但是,要实现这些目标,就需要对骨骼-材料界面处的事件有更好的了解,并需要开发新的材料和方法来促进骨整合。在这里,我们提出了来自塔塔拉的新型纳米结构纳米阵列,可以促进细胞粘附和分化。我们的结果表明,塔塔拉纳米管阵列可增强成骨细胞的粘附,增殖和分化。塔塔拉纳米管阵列的制造路线是灵活且具有成本效益的,从而能够在现有的非平面骨科植入物上实现所需的平台拓扑。

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