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首页> 外文期刊>Nanotechnology >Nanostructured materials based on the integration of ferrocenyl-tethered dendrimer and redox proteins on self-assembled monolayers: an efficient biosensor interface
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Nanostructured materials based on the integration of ferrocenyl-tethered dendrimer and redox proteins on self-assembled monolayers: an efficient biosensor interface

机译：基于二茂铁基束缚的树枝状大分子和氧化还原蛋白在自组装单层上的整合的纳米结构材料：有效的生物传感器界面

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In this paper we report the use of ferrocenyl-tethered dendrimer (Fc-D) as an electrode modifier supported by a self-assembled monolayer coated gold surface. The pretreatment of electrodes with Fc-D allows the covalent immobilization of glucose oxidase. The resulting integrated hybrid system provides electrical contact between the redox center of the enzyme and the electrode, and improves the overall bioelectrocatalyzed oxidation of glucose. Cyclic voltammetry combined with surface plasmon resonance (SPR) is used to investigate the redox-induced orientation changes of ferrocene-tethered dendrimers and the optimal electrical wiring of the enzyme, depending on the length of the alkyl chain of the ferrocene-tethered groups. The amount of substrate controls the steady-state concentration ratio of Fc/Fc(+) in the film composition. Therefore, the SPR spectrum of the film is controlled by the reversible change in the refractive index of the enzyme-integrated redox film. The proposed method demonstrates a new procedure for developing a stable amperometric redox enzyme-based sensor by designing a new nanostructured material that control the biosensing performance.
机译：在本文中，我们报告了使用二茂铁基拴链的树枝状大分子（Fc-D）作为自修饰单层涂层金表面支持的电极改性剂的用途。用Fc-D预处理电极可共价固定葡萄糖氧化酶。所得的集成杂化系统在酶的氧化还原中心与电极之间提供电接触，​​并改善了葡萄糖的整体生物电催化氧化。循环伏安法与表面等离振子共振（SPR）相结合，用于研究氧化铁诱导的二茂铁束缚的树枝状大分子的取向变化以及酶的最佳电气布线，具体取决于二茂铁束缚的基团的烷基链长度。底物的量控制膜组合物中Fc / Fc（+）的稳态浓度比。因此，通过整合酶的氧化还原膜的折射率的可逆变化来控制膜的SPR光谱。所提出的方法通过设计一种控制生物传感性能的新型纳米结构材料，展示了开发稳定的基于安培氧化还原酶的传感器的新程序。

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