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Long-term hepatotoxicity of polyethylene-glycol functionalized multi-walled carbon nanotubes in mice

机译：聚乙二醇功能化多壁碳纳米管对小鼠的长期肝毒性

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摘要

The toxicity of polyethylene-glycol functionalized (PEGylated) multi-walled carbon nanotubes (MWCNTs) and non-PEGylated MWCNTs in vivo was evaluated and compared. Mice were exposed to MWCNTs by intravenous injection. The activity level of glutathione, superoxide dismutase and gene expression in liver, as well as some biochemical parameters and the tumor necrosis factor alpha level in blood were measured over 2 months. The pathological and electron micrographic observations of liver evidently indicate that the damage caused by non-PEGylated MWCNTs is slightly more severe than that of PEGylated MWCNTs, which means that PEGylation can partly, but not substantially, improve the in vivo biocompatibility of MWCNTs.
机译：评估和比较了聚乙二醇功能化（聚乙二醇化）多壁碳纳米管（MWCNT）和非聚乙二醇化MWCNT的体内毒性。通过静脉内注射使小鼠暴露于MWCNT。在2个月的时间内测量了肝脏中谷胱甘肽的活性水平，超氧化物歧化酶和基因表达，以及血液中的一些生化参数和肿瘤坏死因子α水平。肝脏的病理学和电子显微观察清楚地表明，由非聚乙二醇化的多壁碳纳米管引起的损害比聚乙二醇化的多壁碳纳米管所造成的损害要严重得多，这意味着聚乙二醇化可以部分但不显着改善聚碳纳米管的体内生物相容性。

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