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首页> 外文期刊>Nanotechnology >PH-stimuli-responsive near-infrared optical imaging nanoprobe based on poly(γ-glutamic acid)/poly(β-amino ester) nanoparticles
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PH-stimuli-responsive near-infrared optical imaging nanoprobe based on poly(γ-glutamic acid)/poly(β-amino ester) nanoparticles

机译：基于聚（γ-谷氨酸）/聚（β-氨基酯）纳米粒子的PH刺激响应型近红外光学成像纳米探针

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摘要

pH-stimuli-responsive near-infrared optical imaging nanoprobes are designed and synthesized in this study in a facile one-step synthesis process based on the use of the biocompatible and biodegradable polymer poly(γ-glutamic acid) (γ-PGA)/poly(β-amino ester) (PBAE). PBAE has good transfection efficiency and promotes degradation properties under acidic conditions. This pH-responsive degradability can be used for the effective release of encapsulating materials after cellular uptake. As an optical imaging probe, indocyanine green (ICG) is an FDA-approved near-infrared fluorescent dye with a quenching property at a high concentration. In this regard, we focus here on the rapid degradation of PBAE in an acidic environment, in which the nanoparticles are disassembled. This allows the ICG dyes to show enhanced fluorescence signals after being releasing from the particles. We demonstrated this principle in cellular uptake experiments. We expect that the developed pH-stimuli-responsive smart nanoprobes can be applied in intracellular delivery signaling applications.
机译：在这项研究中，基于生物相容性和可生物降解的聚合物聚（γ-谷氨酸）/（γ-PGA）/ poly的设计，设计并合成了pH刺激响应近红外光学成像纳米探针。 （β-氨基酯）（PBAE）。 PBAE在酸性条件下具有良好的转染效率并促进降解性能。这种pH响应降解性可用于细胞摄取后有效释放封装材料。作为光学成像探针，吲哚菁绿（ICG）是FDA批准的具有高浓度猝灭特性的近红外荧光染料。在这方面，我们在这里集中于在酸性环境中PBAE的快速降解，在酸性环境中纳米颗粒被分解。这使ICG染料从颗粒中释放后，显示出增强的荧光信号。我们在细胞摄取实验中证明了这一原理。我们期望开发的pH刺激响应智能纳米探针可以应用于细胞内传递信号的应用。

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