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首页> 外文期刊>Nanotechnology >Electrically controlled drug release from nanostructured polypyrrole coated on titanium
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Electrically controlled drug release from nanostructured polypyrrole coated on titanium

机译：电控制药物从钛涂层纳米结构聚吡咯的释放

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Previous studies have demonstrated that multi-walled carbon nanotubes grown out of anodized nanotubular titanium (MWNT-Ti) can be used as a sensing electrode for various biomedical applications; such sensors detected the redox reactions of certain molecules, specifically proteins deposited by osteoblasts during extracellular matrix bone formation. Since it is known that polypyrrole (PPy) can release drugs upon electrical stimulation, in this study antibiotics (penicillin/streptomycin, P/S) or an anti-inflammatory drug (dexamethasone, Dex), termed PPy[P/S] or PPy[Dex], respectively, were electrodeposited in PPy on titanium. The objective of the present study was to determine if such drugs can be released from PPy on demand and (by applying a voltage) control cellular behavior important for orthopedic applications. Results showed that PPy films possessed nanometer-scale roughness as analyzed by atomic force microscopy. X-ray photoelectron spectroscopy confirmed the presence of P/S and Dex encapsulated within the PPy films. Results from cyclic voltammetry showed that 80% of the drugs were released on demand when sweep voltages were applied for five cycles at a scan rate of 0.1 V s~(-1). Furthermore, osteoblast (bone-forming cells) and fibroblast (fibrous tissue-forming cells) adhesion were determined on the PPy films. Results showed that PPy[Dex] enhanced osteoblast adhesion after 4 h of culture compared to plain Ti. PPy-Ti (with or without anionic drug doping) inhibited fibroblast adhesion compared to plain Ti. These in vitro results confirmed that electrodeposited PPy[P/S] and PPy[Dex] can release drugs on demand to potentially fight bacterial infection, reduce inflammation, promote bone growth or reduce fibroblast functions, further implicating the use of such materials as implant sensors.
机译：先前的研究表明，由阳极氧化纳米管钛（MWNT-Ti）制成的多壁碳纳米管可用作各种生物医学应用的传感电极。这种传感器检测到某些分子的氧化还原反应，特别是成骨细胞在细胞外基质骨形成过程中沉积的蛋白质。由于已知聚吡咯（PPy）会在电刺激下释放药物，因此在本研究中，抗生素（青霉素/链霉素，P / S）或抗炎药（地塞米松，Dex）被称为PPy [P / S]或PPy [Dex]分别在PPy中电沉积在钛上。本研究的目的是确定这些药物是否可以按需从PPy中释放出来，并（通过施加电压）控制对于骨科应用很重要的细胞行为。结果显示，通过原子力显微镜分析，PPy膜具有纳米级的粗糙度。 X射线光电子能谱证实了PPy膜中包裹的P / S和Dex的存在。循环伏安法的结果表明，当以0.1 V s〜（-1）的扫描速率施加五个扫描周期时，有80％的药物按需释放。此外，在PPy膜上确定成骨细胞（成骨细胞）和成纤维细胞（成纤维组织形成细胞）的粘附。结果表明，与普通Ti相比，PPy [Dex]在培养4 h后可增强成骨细胞粘附。与纯钛相比，PPy-Ti（有或没有阴离子药物掺杂）抑制成纤维细胞粘附。这些体外结果证实，电沉积的PPy [P / S]和PPy [Dex]可以按需释放药物，以潜在地抵抗细菌感染，减少炎症，促进骨骼生长或降低成纤维细胞功能，进一步牵涉使用此类材料作为植入物传感器。

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