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首页> 外文期刊>Microbes and infection >Allergen-specific IgE and IgG4 are markers of resistance and susceptibility in a human intestinal nematode infection
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Allergen-specific IgE and IgG4 are markers of resistance and susceptibility in a human intestinal nematode infection

机译：过敏原特异性IgE和IgG4是人肠道线虫感染中抗药性和敏感性的标志物

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IgG4 has been proposed to act as a 'blocking antibody' due to its ability to compete for the same epitopes as IgE thus preventing IgE-dependent allergic responses. IgG4 and IgE are both elevated in helminth infections and strong anti-parasite IgE responses are associated with resistance to infection. We wished to determine the relationship between anti-parasite IgG4 and IgE and Ascaris lumbricoides infection status. We examined anti-parasite responses, including antibody levels to recombinant Ascaris allergen-1A (rABA-1A), a target of serum IgE in endemic populations. Worm burden was indirectly estimated by measuring parasite egg output in a cross-sectional human population (N = 105). Levels of anti-parasite IgG4 and IgE in patients' plasma were quantified by immunoassay. Global anti-parasite antibody responses did not bear any significant relationships with intensity of Ascaris infection. Individuals who had detectable levels of IgE but not IgG4 to rABA-1A (11%) had lower average levels of infection compared with individuals who produced anti-rABA-1A IgG4 (40%) and sero-negative individuals (49%) (P = 0.008). The ratio of IgG4/IgE in rABA-1A responders positively correlated with intensity of infection (P < 0.025). IgG4 levels positively correlated with infection level in younger children (age 4-11) where average levels of infection were increasing (P = 0.038), whereas allergen specific IgE emerged as a correlate of immunity in older children and adults (age 12-36) where infection levels were decreasing (P = 0.048). Therefore, in a gastrointestinal helminth infection, differential regulation of anti-allergen antibody isotypes relate to infection level. Our results are consistent with the concept that IgG4 antibody can block IgE-mediated immunity and therefore allergic processes in humans. (c) 2005 Elsevier SAS. All rights reserved.
机译：IgG4由于其与IgE竞争相同表位的能力而被提议充当“封闭抗体”，从而防止了IgE依赖性过敏反应。 IgG4和IgE在蠕虫感染中均升高，并且强大的抗寄生虫IgE反应与对感染的抵抗力相关。我们希望确定抗寄生虫IgG4和IgE与A虫的感染状况之间的关系。我们检查了抗寄生虫反应，包括针对重组A虫过敏原1A（rABA-1A）（在地方性人群中血清IgE的靶标）的抗体水平。通过测量横断面人群（N = 105）的寄生虫卵产量来间接估算蠕虫负担。通过免疫测定来量化患者血浆中抗寄生虫IgG4和IgE的水平。总体抗寄生虫抗体反应与A虫感染强度没有任何显着关系。与可产生r-rABA-1A IgG4的个体（40％）和血清阴性的个体（49％）相比，可检测到rABA-1A的IgE水平但未检测到IgG4的个体（11％）的平均感染水平较低（P = 0.008）。 rABA-1A应答者中IgG4 / IgE的比例与感染强度呈正相关（P <0.025）。 IgG4水平与平均感染水平升高的幼儿（4-11岁）的感染水平呈正相关（P = 0.038），而变应原特异性IgE则与年龄较大的儿童和成年人（12-36岁）的免疫力相关。感染水平正在下降（P = 0.048）。因此，在胃肠蠕虫感染中，抗过敏原抗体同种型的差异调节与感染水平有关。我们的结果与IgG4抗体可以阻断IgE介导的免疫力并因此抑制人类的过敏过程这一概念相符。 （c）2005 Elsevier SAS。版权所有。

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