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首页> 外文期刊>Microbes and infection >Augmentation of antimicrobial metronidazole therapy of bacterial vaginosis with oral probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14: randomized, double-blind, placebo controlled trial.
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Augmentation of antimicrobial metronidazole therapy of bacterial vaginosis with oral probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14: randomized, double-blind, placebo controlled trial.

机译：口服益生菌鼠李糖乳杆菌GR-1和罗伊氏乳杆菌RC-14增强抗菌素甲硝唑治疗细菌性阴道病的随机，双盲，安慰剂对照试验。

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This study enrolled 125 premenopausal women diagnosed with bacterial vaginosis (BV) by presence of vaginal irritation, discharge and 'fishy' odor, and Nugent criteria and detection of sialidase enzyme. The subjects were treated with oral metronidazole (500 mg) twice daily from days 1 to 7, and randomized to receive oral Lactobacillus rhamnosus GR-1 (1 x 10(9)) and Lactobacillus reuteri RC-14 (1 x 10(9)) or placebo twice daily from days 1 to 30. Primary outcome was cure of BV as determined by normal Nugent score, negative sialidase test and no symptoms or signs of BV at day 30. A total of 106 subjects returned for 30-day follow-up, of which 88% were cured in the antibiotic/probiotic group compared to 40% in the antibiotic/placebo group (p<0.001). Of the remaining subjects, 30% subjects in the placebo group and none in the probiotic group had BV, while 30% in the placebo and 12% in the probiotic group fell into the intermediate category based upon Nugent score, sialidase result and clinical findings. High counts of Lactobacillus sp. (>10(5) CFU/ml) were recovered from the vagina of 96% probiotic-treated subjects compared to 53% controls at day 30. In summary, this study showed efficacious use of lactobacilli and antibiotic in the eradication of BV in black African women.
机译：这项研究招募了125名经阴道刺激，分泌物和“鱼腥味”以及Nugent标准和唾液酸酶检测诊断为细菌性阴道病（BV）的绝经前妇女。从第1天到第7天，每天两次口服甲硝唑（500 mg）治疗受试者，并随机接受口服鼠李糖乳杆菌GR-1（1 x 10（9））和罗伊氏乳杆菌RC-14（1 x 10（9）） ）或安慰剂，从第1天到第30天每天两次。主要结局是通过正常Nugent评分，唾液酸酶测试阴性，在第30天没有BV症状或体征确定的BV治愈。总共有106名受试者在30天后返回-最多，其中抗生素/益生菌组中88％治愈，而抗生素/安慰剂组中40％（p <0.001）。在其余受试者中，根据Nugent评分，唾液酸酶结果和临床发现，安慰剂组中30％的受试者，而益生菌组中没有一例具有BV，而安慰剂组中的30％和益生菌组中的12％属于中级。高数量的乳酸杆菌。 （> 10（5）CFU / ml）在第30天时从96％的经益生菌治疗的受试者的阴道中回收，而对照组的这一比例为53％。总而言之，这项研究表明有效使用乳杆菌和抗生素来根除黑人中的BV非洲妇女。

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