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首页> 外文期刊>Microbes and infection >Salmonella vaccines secreting measles virus epitopes induce protective immune responses against measles virus encephalitis.
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Salmonella vaccines secreting measles virus epitopes induce protective immune responses against measles virus encephalitis.

机译：分泌麻疹病毒表位的沙门氏菌疫苗可诱导针对麻疹病毒脑炎的保护性免疫应答。

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摘要

In the present study we describe a live vaccine against measles virus (MV) infection on the basis of attenuated Salmonella typhimurium aroA secreting MV antigens via the Escherichia coli alpha-hemolysin secretion system. Two well-characterized MV epitopes, a B-cell epitope of the MV fusion protein (amino acids 404-414) and a T-cell epitope of the MV nucleocapsid protein (amino acids 79-99) were fused as single or repeating units to the C-terminal secretion signal of the E. coli hemolysin and expressed in secreted form by the attenuated S. typhimurium aroA SL7207. Immunization of MV-susceptible C3H mice revealed that S. typhimurium SL7207 secreting these antigens provoked a humoral and a cellular MV-specific immune response, respectively. Mice vaccinated orally with a combination of both recombinant S. typhimurium strains showed partial protection against a lethal MV encephalitis after intracerebral challenge with a rodent-adapted, neurotropic MV strain.
机译：在本研究中，我们通过减毒的鼠伤寒沙门氏菌aroA通过大肠杆菌α-溶血素分泌系统分泌MV抗原，描述了一种针对麻疹病毒（MV）感染的活疫苗。将两个特征明确的MV表位，MV融合蛋白的B细胞表位（氨基酸404-414）和MV核衣壳蛋白的T细胞表位（氨基酸79-99）作为单个或重复单元融合到大肠杆菌溶血素的C端分泌信号，并以减毒鼠伤寒沙门氏菌aroA SL7207的分泌形式表达。 MV易感性C3H小鼠的免疫反应表明，分泌这些抗原的鼠伤寒沙门氏菌SL7207分别引起体液和细胞MV特异性免疫反应。口服接种两种重组鼠伤寒沙门氏菌菌株的小鼠，在用适应啮齿动物的神经质MV菌株脑内攻击后，对致命的MV脑炎表现出部分保护作用。

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