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A versatile synthesis of highly bactericidal Myramistin (R) stabilized silver nanoparticles

机译:高度杀菌的Myramistin(R)稳定的银纳米粒子的通用合成

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Silver nanoparticles stabilized by a well-known antibacterial surfactant benzyldimethyl[3-(myristoylamino) propyl] ammonium chloride (Myramistin (R)) were produced for the first time by borohydride reduction of silver chloride sol in water. Stable aqueous dispersions of silver nanoparticles without evident precipitation for several months could be obtained. In vitro bactericidal tests showed that Myramistin (R) capped silver NPs exhibited notable activity against six different microorganisms -gram-positive and gram-negative bacteria, yeasts and fungi. The activity was up to 20 times higher (against E. coli) compared to Myramistin (R) at the same concentrations and on average 2 times higher if compared with citrate-stabilized NPs.
机译:通过在水中将氯化银溶胶氢硼化还原,首次生产了由众所周知的抗菌表面活性剂苄基二甲基[3-(肉豆蔻基氨基)丙基]氯化铵(Myramistin(R))稳定的银纳米颗粒。可以获得数月没有明显沉淀的稳定的银纳米颗粒水分散体。体外杀菌试验表明,Myramistin(R)封端的银纳米粒对六种不同的微生物(革兰氏阳性菌和革兰氏阴性菌,酵母菌和真菌)表现出显着的活性。在相同浓度下,该活性比Myramistin(R)高出20倍(针对大肠杆菌),如果与柠檬酸盐稳定的NP相比,则平均高出2倍。

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