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Base dependent DNA-carbon nanotube interactions: activation enthalpies and assembly-disassembly control

机译:依赖碱基的DNA-碳纳米管相互作用:活化焓和组装-拆卸控制

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We quantify the base dependent interactions between single stranded DNA and single walled carbon nanotubes (SWNTs) in solution. DNA/SWNT hybrids hold the promise of applications ranging from nanoscale electronics and assembly of nanotube based materials, to drug delivery and DNA sequencing. These applications require control over the hybrid assembly and disassembly. Our analytical assay reveals the order of nucleobase binding strengths with SWNTs as G > C > A > T. Furthermore, time dependent fixed temperature experiments that probe the kinetics of the dissociation process provide values for the equilibrium constants and dissociation enthalpies that underlie the microscopic interactions. Quantifying the base dependency of hybrid stability shows how insight into the energetics of the component interactions facilitates control over hybrid assembly and disassembly.
机译:我们量化溶液中单链DNA和单壁碳纳米管(SWNTs)之间的碱基依赖性相互作用。 DNA / SWNT杂化物具有广阔的应用前景,从纳米级电子产品和基于纳米管的材料组装到药物递送和DNA测序。这些应用需要对混合装配和拆卸进行控制。我们的分析测定揭示了SWNT的核碱基结合强度的顺序为G> C> A>T。此外,探测解离过程动力学的时间依赖性固定温度实验提供了作为微观相互作用基础的平衡常数和解离焓值。量化混合动力稳定性的基本依赖性显示了对零件相互作用的能量学的洞察力如何促进对混合动力装配和拆卸的控制。

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