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首页> 外文期刊>Nanotechnology >Immunostimulatory properties and enhanced TNF-alpha mediated cellular immunity for tumor therapy by C-60(OH)(20) nanoparticles
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Immunostimulatory properties and enhanced TNF-alpha mediated cellular immunity for tumor therapy by C-60(OH)(20) nanoparticles

机译：C-60（OH）（20）纳米粒子在肿瘤治疗中的免疫刺激特性和增强的TNF-α介导的细胞免疫

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Publications concerning the mechanism of biological activity, especially the immunological mechanism of C-60(OH)(20) nanoparticles, are relatively limited. However, the structure and characteristics of this carbon allotrope have been widely investigated. In this paper, we have demonstrated that water-soluble C-60(OH)(20) nanoparticles have an efficient anti-tumor activity in vivo, and show specific immunomodulatory effects to the immune cells, such as T cells and macrophages, both in vivo and in vitro. For example, C-60(OH)(20) nanoparticles can increase the production of T-helper cell type 1 (Th1) cytokines (IL-2, IFN-gamma and TNF-alpha), and decrease the production of Th2 cytokines (IL-4, IL-5 and IL-6) in serum samples. On the other hand, C-60(OH)(20) nanoparticles show almost no adverse effect to the viability of immune cells in vitro but stimulate the immune cells to release more cytokines, in particular TNF-alpha, which plays a key role in the cellular immune process to help eliminate abnormal cells. TNF-alpha production increased almost three-fold in treated T lymphocytes and macrophages. Accordingly, we conclude that C-60(OH)(20) nanoparticles have an efficient anti-tumor activity and this effect is associated with an increased CD4+/CD8+ lymphocyte ratio and the enhancement of TNF-alpha production. The data suggest that C-60(OH)(20) nanoparticles can improve the immune response to help to scavenge and kill tumor cells.
机译：有关生物活性机制，尤其是C-60（OH）（20）纳米粒子的免疫机制的出版物相对有限。但是，已经对该碳同素异形体的结构和特性进行了广泛研究。在本文中，我们证明了水溶性C-60（OH）（20）纳米粒子在体内具有有效的抗肿瘤活性，并且对免疫细胞（例如T细胞和巨噬细胞）均具有特异性的免疫调节作用。体内和体外。例如，C-60（OH）（20）纳米颗粒可以增加T型辅助细胞1型（Th1）细胞因子（IL-2，IFN-γ和TNF-alpha）的产生，并减少Th2细胞因子的产生（ IL-4，IL-5和IL-6）。另一方面，C-60（OH）（20）纳米粒子在体外对免疫细胞的存活率几乎没有不利影响，但是刺激免疫细胞释放更多的细胞因子，特别是TNF-α，在体内起关键作用。细胞免疫过程有助于消除异常细胞。在处理过的T淋巴细胞和巨噬细胞中，TNF-α的产量增加了近三倍。因此，我们得出结论，C-60（OH）（20）纳米粒子具有有效的抗肿瘤活性，并且这种作用与CD4 + / CD8 +淋巴细胞比例增加和TNF-α产生的增强有关。数据表明，C-60（OH）（20）纳米颗粒可以改善免疫反应，以帮助清除和杀死肿瘤细胞。

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