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首页> 外文期刊>Nanotechnology >Protective effect of maghemite nanoparticles on ultraviolet-induced photo-damage in human skin fibroblasts
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Protective effect of maghemite nanoparticles on ultraviolet-induced photo-damage in human skin fibroblasts

机译：磁赤铁矿纳米粒子对紫外线引起的人皮肤成纤维细胞光损伤的保护作用

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摘要

This study examined the optical properties of an oxidized form of maghemite (gamma-Fe_2O_3) nanoparticles and their protective effects against the photoaging of human skin fibroblasts irradiated with ultraviolet (UV) light. Nanoparticles with diameters ranging from 8.7 to 12 nm were prepared using a chemical co-precipitation method. The nanoparticles were coated with two surfactants to obtain a water-based product. The onset of the absorption of the gamma-Fe_2O_3 nanoparticles in the UV-visible absorption spectra increased with increasing particle size. The gamma-Fe_2O_3 nanoparticles significantly inhibited the production of matrix metalloproteinase-1 in human skin fibroblast HS 68 cells by 60 percent compared with the UV-irradiated control. These results suggest that gamma-Fe_2O_3 nanoparticles have photoprotective properties, and have potential use as an agent against photoaging.
机译：这项研究检查了氧化形式的磁赤铁矿（gamma-Fe_2O_3）纳米颗粒的光学性质及其对用紫外线（UV）照射的人类皮肤成纤维细胞光老化的保护作用。使用化学共沉淀法制备了直径为8.7至12 nm的纳米颗粒。用两种表面活性剂涂覆纳米颗粒以获得水基产物。随着粒径的增加，γ-Fe_2O_3纳米粒子在紫外可见吸收光谱中的吸收开始。与紫外线照射的对照组相比，γ-Fe_2O_3纳米颗粒显着抑制了人类皮肤成纤维细胞HS 68细胞中基质金属蛋白酶-1的生成，降低了60％。这些结果表明，γ-Fe_2O_3纳米粒子具有光保护性能，并具有潜在的抗光老化作用。

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