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Carbon nanotubes for biological and biomedical applications

机译：用于生物和生物医学应用的碳纳米管

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Ever since the discovery of carbon nanotubes, researchers have been exploring their potential in biological and biomedical applications. The recent expansion and availability of chemical modification and bio-functionalization methods have made it possible to generate a new class of bioactive carbon nanotubes which are conjugated with proteins, carbohydrates, or nucleic acids. The modification of a carbon nanotube on a molecular level using biological molecules is essentially an example of the 'bottom-up' fabrication principle of bionanotechnology. The availability of these biomodified carbon nanotube constructs opens up an entire new and exciting research direction in the field of chemical biology, finally aiming to target and to alter the cell's behaviour at the subcellular or molecular level. This review covers the latest advances of bio-functionalized carbon nanotubes with an emphasis on the development of functional biological nano-interfaces. Topics that are discussed herewith include methods for biomodification of carbon nanotubes, the development of hybrid systems of carbon nanotubes and biomolecules for bioelectronics, and carbon nanotubes as transporters for a specific delivery of peptides and/or genetic material to cells. All of these current research topics aim at translating these biotechnology modified nanotubes into potential novel therapeutic approaches.
机译：自从发现碳纳米管以来，研究人员一直在探索其在生物和生物医学应用中的潜力。化学修饰和生物功能化方法的最新扩展和可用性使得产生与蛋白质，碳水化合物或核酸缀合的新型生物活性碳纳米管成为可能。使用生物分子在分子水平上修饰碳纳米管本质上是仿生纳米技术“自下而上”制造原理的一个示例。这些生物修饰的碳纳米管构建体的可用性为化学生物学领域开辟了一个全新的，令人兴奋的研究方向，最终旨在在亚细胞或分子水平上靶向并改变细胞的行为。这篇综述涵盖了生物功能化碳纳米管的最新进展，重点是功能性生物纳米界面的开发。此处讨论的主题包括碳纳米管的生物修饰方法，碳纳米管与生物电子生物分子的混合系统的开发以及碳纳米管作为将肽和/或遗传物质特异性递送至细胞的转运蛋白。所有这些当前的研究主题旨在将这些生物技术修饰的纳米管转化为潜在的新型治疗方法。

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