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DNA-directed self-assembly of gold nanoparticles into binary and ternary nanostructures

机译：DNA定向的金纳米粒子自组装成二元和三元纳米结构

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摘要

The assembly and characterization of gold nanoparticle-based binary and ternary structures are reported. Two strategies were used to assemble gold nanoparticles into ordered nanoscale architectures: in strategy 1, gold nanoparticles were functionalized with single-strand DNA (ssDNA) first, and then hybridized with complementary ssDNA-labelled nanoparticles to assemble designed architectures. In strategy 2, the designed architectures were constructed through hybridization between complementary ssDNA first, then by assembling gold nanoparticles to the scaffolding through gold-sulfur bonds. Both TEM measurements and agarose gel electrophoresis confirmed that the latter strategy is more efficient in generating the designed nanostructures.
机译：报告了金纳米粒子基二元和三元结构的组装和表征。使用两种策略将金纳米颗粒组装成有序的纳米级体系结构：在策略1中，首先将金纳米颗粒用单链DNA（ssDNA）功能化，然后与互补的ssDNA标记的纳米颗粒杂交以组装设计的体系结构。在策略2中，首先通过互补ssDNA之间的杂交来构建设计的体系结构，然后通过金-硫键将金纳米颗粒组装到支架上。 TEM测量和琼脂糖凝胶电泳均证实，后一种方法在生成设计的纳米结构方面更有效。

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