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Fabrication of functional nano-patterned surfaces by a combination of plasma processes and electron-beam lithography

机译:结合等离子体工艺和电子束光刻技术制造功能性纳米图案表面

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摘要

This work presents a method for the fabrication of well defined chemically active nano-patterned surfaces. Electron-beam lithography has been combined with plasma-based processes in order to create sub-micron carboxylic functional areas over a non-bio-adhesive matrix. Characterization of the patterned surface by several surface analysis techniques reveals that this patterning technique is compatible with the plasma polymerization process in order to fabricate chemically active features with lateral size down to 300 nm. Moreover, experiments with a model protein ( bovine serum albumin) on the patterned surfaces show preferential adhesion on the active region indicating the ability of this method for the design of biosensing platforms.
机译:这项工作提出了一种用于制造定义明确的化学活性纳米图案表面的方法。电子束光刻技术已与基于等离子体的工艺相结合,以便在非生物粘附基质上形成亚微米级的羧基功能区。通过几种表面分析技术表征的图案化表面表明,该图案化技术与等离子体聚合工艺兼容,以便制造横向尺寸低至300 nm的化学活性特征。此外,在图案化表面上使用模型蛋白(牛血清白蛋白)进行的实验表明,在活性区域上存在优先粘附,表明该方法具有设计生物传感平台的能力。

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