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首页> 外文期刊>Nanotechnology >A lactate electrochemical biosensor with a titanate nanotube as direct electron transfer promoter
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A lactate electrochemical biosensor with a titanate nanotube as direct electron transfer promoter

机译：以钛酸酯纳米管为直接电子转移促进剂的乳酸电化学生物传感器

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Hydrogen titanate (H2Ti3O7) nanotubes (TNTs) have been synthesized by a one-step hydrothermal processing. Lactate oxidase (LOx) enzyme has been immobilized on the three-dimensional porous TNT network to make an electrochemical biosensor for lactate detection. Cyclic voltammetry and amperometry tests reveal that the LOx enzyme, which is supported on TNTs, maintains their substrate-specific catalytic activity. The nanotubes offer the pathway for direct electron transfer between the electrode surface and the active redox centers of LOx, which enables the biosensor to operate at a low working potential and to avoid the influence of the presence of O-2 on the amperometric current response. The biosensor exhibits a sensitivity of 0.24 mu A cm(-2) mM(-1), a 90% response time of 5 s, and a linear response in the range from 0.5 to 14 mM and the redox center of enzyme obviates the need of redox mediators for electrochemical enzymatic sensors, which is attractive for the development of reagentless biosensors.
机译：钛酸氢盐（H2Ti3O7）纳米管（TNTs）已经通过一步水热法合成。乳酸氧化酶（LOx）酶已被固定在三维多孔TNT网络上，以制造用于乳酸检测的电化学生物传感器。循环伏安法和安培法测试表明，TNT上支持的LOx酶保持了其底物特异性催化活性。纳米管为电极表面与LOx的活性氧化还原中心之间的直接电子转移提供了途径，这使生物传感器能够在低工作电势下运行，并避免O-2的存在对安培电流响应的影响。该生物传感器显示出0.24μAcm（-2）mM（-1）的灵敏度，90％的响应时间为5 s和0.5至14 mM的线性响应，并且酶的氧化还原中心消除了需要用于电化学酶传感器的氧化还原介体的研究，对无试剂生物传感器的开发具有吸引力。

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