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首页> 外文期刊>Nanotechnology >Facile one-pot preparation and functionalization of luminescent chitosan-poly(methacrylic acid) microspheres based on polymer-monomer pairs
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Facile one-pot preparation and functionalization of luminescent chitosan-poly(methacrylic acid) microspheres based on polymer-monomer pairs

机译：基于聚合物-单体对的发光壳聚糖-聚（甲基丙烯酸）微球的便捷一锅制备和功能化

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摘要

In this paper, we present a facile and robust approach to synthesize multifunctional organic/inorganic composite microspheres with chitosan-poly(methacrylic acid) (CS-PMAA) shells and cadmium tellurium/iron oxide nanoparticle cores. Due to the strong electrostatic interaction between the negatively charged nanoparticles and the protonated CS polymers, the CSanoparticle complexes were utilized as templates for the subsequent polymerization of methacrylic acid. The resulting composite microspheres with luminescence and magnetic properties have regular morphologies and narrow size distributions. In contrast to previous reports, this route was based on a one-pot strategy without the aid of surfactants, organic solvent, or polymerizable ligands in aqueous solution. The encapsulated CdTe semiconductor nanocrystals inside the microspheres exhibited strong and stable photoluminescence properties in the pH range 5.0-11.0. When the pH was adjusted below 4, the photoluminescence decreased sharply and even quenched completely. However, the weakened fluorescence emission could be recovered to some degree upon an increase of pH above 5. Additionally, when both Fe3O4 and CdTe nanoparticles were encapsulated within CS-PMAA microspheres, the magnetic content of the microspheres could be efficiently controlled by tuning the feeding molar ratio of MAA monomers and glucosamine units of CS. From the preliminary attempts, it was found that the multifunctional microspheres as imaging agents could improve the rate and extent of cellular uptake under short-term exposure to an applied magnetic field, and so exhibit a great potential as bioactive molecule carriers.
机译：在本文中，我们提出了一种简便而稳健的方法，可以合成具有壳聚糖-聚（甲基丙烯酸）（CS-PMAA）壳和碲化镉/氧化铁纳米粒子核的多功能有机/无机复合微球。由于带负电的纳米粒子与质子化的CS聚合物之间存在强的静电相互作用，因此CS /纳米粒子复合物被用作模板用于随后的甲基丙烯酸聚合。所得的具有发光和磁性的复合微球具有规则的形态和狭窄的尺寸分布。与以前的报告相反，此方法基于一锅法，无需在水溶液中使用表面活性剂，有机溶剂或可聚合的配体。微球内部的封装的CdTe半导体纳米晶体在5.0-11.0的pH范围内显示出强而稳定的光致发光特性。当将pH调节至4以下时，光致发光急剧下降，甚至完全淬灭。然而，当pH值增加到5以上时，减弱的荧光发射可以在一定程度上恢复。此外，当Fe3O4和CdTe纳米颗粒都封装在CS-PMAA微球中时，通过调节进料量可以有效地控制微球的磁性MAA单体的摩尔比和CS的葡糖胺单元。从初步的尝试，发现多功能微球作为显像剂可以在短期暴露于外加磁场下提高细胞摄取的速率和程度，因此具有作为生物活性分子载体的巨大潜力。

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