Characterizing proton relaxation times for metallic and magnetic layer-by-layer-coated, DNA-templated nanoparticle chains

Jaganathan H.; Gieseck R.L.; Ivanisevic A.

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Characterizing proton relaxation times for metallic and magnetic layer-by-layer-coated, DNA-templated nanoparticle chains

机译：表征金属和磁性逐层涂覆的DNA模板纳米粒子链的质子弛豫时间

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Metallic and superparamagnetic DNA-templated nanoparticle (NP) chains are examined as potential imaging agents. Proton relaxation times (T_1 and T_2) are measured for DNA nanostructures using nuclear magnetic resonance (NMR) spectroscopy. The layer-by-layer (LBL) method was used to encapsulate the DNA-templated NP chains and demonstrated a change in proton relaxation times. Results from this study suggest that LBL-coated, DNA-templated nanostructures can serve as effective imaging agents for magnetic resonance imaging (MRI) applications.

机译：金属和超顺磁性DNA模板纳米颗粒（NP）链被检查为潜在的成像剂。使用核磁共振（NMR）光谱测量DNA纳米结构的质子弛豫时间（T_1和T_2）。逐层（LBL）方法用于封装以DNA为模板的NP链，并证明了质子弛豫时间的变化。这项研究的结果表明，LBL涂层的DNA模板纳米结构可以作为磁共振成像（MRI）应用的有效成像剂。

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《Nanotechnology》 |2010年第24期|共7页
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Jaganathan H.; Gieseck R.L.; Ivanisevic A.;
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1. Characterizing proton relaxation times for metallic and magnetic layer-by-layer-coated, DNA-templated nanoparticle chains [J] . Jaganathan H., Gieseck R.L., Ivanisevic A. Nanotechnology . 2010,第24期

机译：表征金属和磁性逐层涂覆的DNA模板纳米粒子链的质子弛豫时间
2. Mechanism of Proton Relaxation for Enzyme-Manipulated, Multicomponent Gold-Magnetic Nanoparticle Chains [J] . Jaganathan H., Gieseck R.L., Hudson K., Chemphyschem: A European journal of chemical physics and physical chemistry . 2010,第17期

机译：质子弛豫机理的酶，多组分金磁纳米粒子链。
3. Molecular dynamics simulations of proton transverse relaxation times in suspensions of magnetic nanoparticles [J] . Panczyk Tomasz, Konczak Lukasz, Zapotoczny Szczepan, Journal of Colloid and Interface Science . 2015,第Null期

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5. Characterizing magnetic resonance relaxation times in the extracellular matrix in osteoarthritis and degenerative disc disease. [D] . Blumenkrantz, Gabrielle. 2009

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6. Using Bio-Functionalized Magnetic Nanoparticles and Dynamic Nuclear Magnetic Resonance to Characterize the Time-Dependent Spin-Spin Relaxation Time for Sensitive Bio-Detection [O] . Shu-Hsien Liao, Kuen-Lin Chen, Chun-Min Wang, 2014

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8. NMR (Nuclear Magnetic Resonance) Relaxation Times of Water Protons in Normal Tissues and Cancer Cells: The Role of Paramagnetic Ions [R] . Ling, G. N. 1983

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Characterizing proton relaxation times for metallic and magnetic layer-by-layer-coated, DNA-templated nanoparticle chains

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