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DNA-functionalized solid state nanopore for biosensing

机译:DNA功能化的固态纳米孔用于生物传感

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The possible use of nanopores for single DNA molecules biosensing has been demonstrated, but much remains to do in order to develop advanced engineered devices with enhanced stability, and controlled geometry and surface properties. Here we present morphological and electrical characterization of solid state silicon nitride nanopores fabricated by focused ion beam direct milling and chemically functionalized by probe oligonucleotides, with the final aim of developing a versatile tool for biosensing and gene expression profiling
机译:已经证明可以将纳米孔用于单个DNA分子的生物传感,但是要开发具有增强的稳定性以及可控的几何形状和表面特性的先进工程设备,还有很多工作要做。在这里,我们介绍通过聚焦离子束直接研磨制造并通过探针寡核苷酸化学功能化的固态氮化硅纳米孔的形态和电学表征,其最终目的是开发一种用于生物传感和基因表达谱分析的多功能工具

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