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首页> 外文期刊>Nanotechnology >Carbon nanohorns accelerate bone regeneration in rat calvarial bone defect
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Carbon nanohorns accelerate bone regeneration in rat calvarial bone defect

机译：碳纳米角加速大鼠颅骨缺损的骨再生

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摘要

A recent study showed that carbon nanohorns (CNHs) have biocompatibility and possible medical uses such as in drug delivery systems. It was reported that some kinds of carbon nanomaterials such as carbon nanotubes were useful for bone formation. However, the effect of CNHs on bone tissue has not been clarified. The purpose of this study was to evaluate the effect of CNHs on bone regeneration and their possible application for guided bone regeneration (GBR). CNHs dispersed in ethanol were fixed on a porous polytetrafluoroethylene membrane by vacuum filtration. Cranial defects were created in rats and covered by a membrane with/without CNHs. At two weeks, bone formation under the membrane with CNHs had progressed more than under that without CNHs and numerous macrophages were observed attached to CNHs. At eight weeks, there was no significant difference in the amount of newly formed bone between the groups and the appearance of macrophages was decreased compared with that at two weeks. Newly formed bone attached to some CNHs directly. These results suggest that macrophages induced by CNHs are related to bone regeneration. In conclusion, the present study indicates that CNHs are compatible with bone tissue and effective as a material for GBR.
机译：最近的一项研究表明，碳纳米角（CNHs）具有生物相容性，并可能在药物输送系统等医疗用途中使用。据报道，诸如碳纳米管的某些碳纳米材料可用于骨形成。但是，尚未清楚CNH对骨组织的作用。这项研究的目的是评估CNH对骨再生的影响及其在引导骨再生（GBR）中的可能应用。通过真空过滤将分散在乙醇中的CNH固定在聚四氟乙烯多孔膜上。在大鼠中产生了颅骨缺损，并被带有/不带有CNH的膜覆盖。在两周时，具有CNH的膜下的骨形成比没有CNH的膜下的骨形成进展更多，并且观察到大量巨噬细胞附着于CNH。在八周时，两组之间新形成的骨量没有显着差异，与两周时相比，巨噬细胞的外观减少了。新形成的骨头直接附着在某些CNH上。这些结果表明，CNHs诱导的巨噬细胞与骨再生有关。总而言之，本研究表明CNH与骨骼组织相容并有效用作GBR的材料。

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