Subcutaneous injection of water-soluble multi-walled carbon nanotubes in tumor-bearing mice boosts the host immune activity

Jie Meng; Man Yang; Fumin Jia; Hua Kong; Weiqi Zhang; ChaoyingWang; Jianmin Xing; Sishen Xie; HaiYan Xu

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Subcutaneous injection of water-soluble multi-walled carbon nanotubes in tumor-bearing mice boosts the host immune activity

机译：在荷瘤小鼠中皮下注射水溶性多壁碳纳米管可增强宿主的免疫活性

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The immunological responses induced by oxidized water-soluble multi-walled carbon nanotubes on a hepatocarcinoma tumor-bearing mice model via a local administration of subcutaneous injection were investigated. Experimental results show that the subcutaneously injected carbon nanotubes induced significant activation of the complement system, promoted inflammatory cytokines’ production and stimulated macrophages’ phagocytosis and activation. All of these responses increased the general activity of the host immune system and inhibited the progression of tumor growth.

机译：研究了氧化的水溶性多壁碳纳米管通过局部皮下注射对肝癌荷瘤小鼠模型的免疫反应。实验结果表明，皮下注射的碳纳米管可显着激活补体系统，促进炎症细胞因子的产生，并刺激巨噬细胞的吞噬和激活。所有这些反应增加了宿主免疫系统的总体活性，并抑制了肿瘤生长的进程。

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《Nanotechnology》 |2010年第14期|共9页
作者
Jie Meng; Man Yang; Fumin Jia; Hua Kong; Weiqi Zhang; ChaoyingWang; Jianmin Xing; Sishen Xie; HaiYan Xu;
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正文语种 eng
中图分类特种结构材料;
关键词
host; bearing; activity;

机译：宿主;轴承;活动;

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专利

1. Subcutaneous injection of water-soluble multi-walled carbon nanotubes in tumor-bearing mice boosts the host immune activity [J] . Jie Meng, Man Yang, Fumin Jia, Nanotechnology . 2010,第14期

机译：在荷瘤小鼠中皮下注射水溶性多壁碳纳米管可增强宿主的免疫活性
2. Subcutaneous Injections of the Mannose-Sensitive Hemagglutination Pilus Strain of Pseudomonas aeruginosa Stimulate Host Immunity, Reduce Bladder Cancer Size and Improve Tumor Survival in Mice [J] . Li Tao, Yang Li, Fu Sheng-jun, Cell biochemistry and biophysics . 2015,第1期

机译：铜绿假单胞菌的甘露糖敏感血凝球状菌皮下注射刺激宿主免疫，减少膀胱癌的大小并改善小鼠的肿瘤存活率
3. Pulmonary Toxicity in Mice Exposed to Low and Medium Doses of Water-Soluble Multi-Walled Carbon Nanotubes [J] . X. Wang, J. J. Zang, H. Wang, Journal of nanoscience and nanotechnology . 2010,第12期

机译：中低剂量水溶性多壁碳纳米管暴露于小鼠的肺毒性
4. Anti-tumor effect of BCGHSP70-B16TCL in subcutaneous tumor-bearing mice [C] . He Li, Hua Wang, Min Wan, 2011 International Conference on Human Health and Biomedical Engineering . 2011

机译：BCGHSP70-B16TCL对皮下荷瘤小鼠的抗肿瘤作用
5. A Tale of Two Carbon Nanotubes: Inflammatory, Fibrogenic, and Immune Responses to Tangled and Rod-Like Multi-Walled Carbon Nanotubes in Genetically Susceptible Mouse Models [D] . Duke, Katherine Sue Hlavinka. 2017

机译：两种碳纳米管的故事：炎症，纤维纤维和免疫应答，缠结和棒状多壁碳纳米管在遗传易感小鼠模型中
6. Multi-walled carbon nanotubes functionalized with recombinant Dengue virus 3 envelope proteins induce significant and specific immune responses in mice [O] . Alice F. Versiani, Ruiz G. Astigarraga, Eliseu S. O. Rocha, 2017

机译：用重组登革热病毒3包膜蛋白功能化的多壁碳纳米管在小鼠中诱导明显和特异性的免疫反应
7. Single-Walled and Multi-Walled Carbon Nanotubes Promote Allergic Immune Responses in Mice [O] . Unni C. Nygaard, Jitka S. Hansen, Mari Samuelsen, 2009

机译：单壁和多壁碳纳米管促进小鼠的过敏免疫应答
8. Fabrication and Characterization of Multi-Walled Carbon Nanotube (MWCNT) and Ni-Coated Multi-Walled Carbon Nanotube (Ni-MWCNT) Repair Patches for Carbon Fiber Reinforced Composite Systems [R] . Johnson, B., Caraccio, A., Tate, L. N., 2011

机译：碳纤维增强复合材料多壁碳纳米管（mWCNT）和Ni涂层多壁碳纳米管（Ni-mWCNT）修补补片的制备与表征

Subcutaneous injection of water-soluble multi-walled carbon nanotubes in tumor-bearing mice boosts the host immune activity

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