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Near-infrared quantum-dot-based non-invasive in vivo imaging of squamous cell carcinoma U14

机译：鳞状细胞癌U14的基于近红外量子点的无创体内成像

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摘要

Near-infrared (near-ir) quantum dots (QDs) are well known for their excellent optical characteristics. They hold great potential for applications in non-invasive long term observation and tracing of cells in vivo. Here, near-ir QDs with an emission wavelength of 800 nm (QD800) were used to label squamous cell carcinoma cell line U14 (U14/QD800). The effect of tissue depth and animal fur on the imaging sensitivity and stability was evaluated following subcutaneous and intramuscular injection into Kunming mice, employing an in vivo imaging system. We have demonstrated that QD800-based visual in vivo imaging increased the sensitivity of cancer early detection by a factor of 100 compared with traditional detection methods. More importantly, this study proved for the first time that animal fur has a serious impact on the detection sensitivity and duration of QD-based in vivo imaging. In general, the duration and sensitivity of QD800 for in vivo imaging were not greatly affected by a depth less than 1.8 ± 0.21 mm (subcutaneous or intramuscular). This study provides critical reference data for further research on near-ir QD-based early detection and in vivo visual observation of cancer.
机译：近红外（近红外）量子点（QD）以其出色的光学特性而闻名。它们在非侵入性长期体内观察和追踪细胞中具有巨大的应用潜力。在这里，发射波长为800 nm的近红外QD（QD800）用于标记鳞状细胞癌细胞系U14（U14 / QD800）。在皮下和肌肉内注射昆明小鼠后，采用体内成像系统评估了组织深度和动物毛皮对成像灵敏度和稳定性的影响。我们已经证明，基于QD800的可视体内成像与传统检测方法相比，将癌症早期检测的敏感性提高了100倍。更重要的是，这项研究首次证明了动物皮毛对基于QD的体内成像的检测灵敏度和持续时间有严重影响。通常，QD800在体内成像的持续时间和灵敏度不会受到深度小于1.8±0.21 mm（皮下或肌内）的影响。这项研究为进一步研究基于近红外QD的癌症早期检测和体内视觉观察提供了重要的参考数据。

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